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Lgals12 galectin 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293710, updated on 17-Aug-2024

Summary

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Official Symbol
Lgals12provided by RGD
Official Full Name
galectin 12provided by RGD
Primary source
RGD:1306914
See related
EnsemblRapid:ENSRNOG00000021207 AllianceGenome:RGD:1306914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable integrin binding activity and lactose binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway and lymphatic endothelial cell migration. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytoplasm. Orthologous to human LGALS12 (galectin 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 19.5), Thymus (RPKM 15.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lgals12 in Genome Data Viewer
Location:
1q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (214261216..214272825, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204832065..204842759, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222891626..222903728, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 like 1 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene phospholipase A and acyltransferase 5 Neighboring gene ribosomal protein L7, pseudogene 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity. Hotta K, et al. J Biol Chem, 2001 Sep 7. PMID 11435439
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lactose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lactose binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
galectin-12
Names
lectin, galactose binding, soluble 12
lectin, galactoside-binding, soluble, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106333.1 → NP_001099803.1  galectin-12

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A0A8I6AH52, A6HZQ6, D3ZBX1
    Related
    ENSRNOP00000055927.2, ENSRNOT00000059154.4
    Conserved Domains (2) summary
    smart00908
    Location:195 → 313
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:26 → 160
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    214261216..214272825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286895.1 → XP_063142965.1  galectin-12 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AH52

  2. XM_063286909.1 → XP_063142979.1  galectin-12 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AH52

  3. XM_063286896.1 → XP_063142966.1  galectin-12 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AH52

  4. XM_063286894.1 → XP_063142964.1  galectin-12 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH52, A6HZQ6, D3ZBX1

  5. XM_063286903.1 → XP_063142973.1  galectin-12 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AH52

  6. XM_063286891.1 → XP_063142961.1  galectin-12 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH52, A6HZQ6, D3ZBX1

  7. XM_063286897.1 → XP_063142967.1  galectin-12 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AH52
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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