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Eef1g eukaryotic translation elongation factor 1 gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 293725, updated on 2-Nov-2024

Summary

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Official Symbol
Eef1gprovided by RGD
Official Full Name
eukaryotic translation elongation factor 1 gammaprovided by RGD
Primary source
RGD:1302939
See related
EnsemblRapid:ENSRNOG00000020075 AllianceGenome:RGD:1302939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in response to virus and translational elongation. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 2690.0), Spleen (RPKM 2395.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eef1g in Genome Data Viewer
Location:
1q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215289815..215300421)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205860713..205871319)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225163391..225173997)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 family, member 2 Neighboring gene uncharacterized LOC134483968 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene AHNAK nucleoprotein Neighboring gene U4 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. Sanders J, et al. J Cell Sci, 1996 May. PMID 8743958
  2. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Leong WF, et al. Cell Microbiol, 2006 Apr. PMID 16548883, Free PMC Article
  3. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
  4. Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control. Chen VC, et al. J Proteome Res, 2012 Dec 7. PMID 23106098
  5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94929, MGC114210

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
elongation factor 1-gamma
Names
EF-1-gamma
eEF-1B gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004223.2 → NP_001004223.1  elongation factor 1-gamma

    See identical proteins and their annotated locations for NP_001004223.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098895
    UniProtKB/Swiss-Prot
    Q4FZZ5, Q68FR6
    UniProtKB/TrEMBL
    A0A8I6AK06, A6HZY2
    Related
    ENSRNOP00000027305.4, ENSRNOT00000027305.9
    Conserved Domains (4) summary
    cd03181
    Location:91 → 213
    GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
    cd03044
    Location:4 → 82
    GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
    TIGR01262
    Location:5 → 187
    maiA; maleylacetoacetate isomerase
    pfam00647
    Location:275 → 381
    EF1G; Elongation factor 1 gamma, conserved domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215289815..215300421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FR6.3 GenPept UniProtKB/Swiss-Prot:Q68FR6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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