U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mcee methylmalonyl CoA epimerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 293829, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Mceeprovided by RGD
Official Full Name
methylmalonyl CoA epimeraseprovided by RGD
Primary source
RGD:1309966
See related
EnsemblRapid:ENSRNOG00000016327 AllianceGenome:RGD:1309966
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable methylmalonyl-CoA epimerase activity. Predicted to be involved in L-methylmalonyl-CoA metabolic process. Predicted to be located in mitochondrion. Orthologous to human MCEE (methylmalonyl-CoA epimerase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 285.6), Adrenal (RPKM 268.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mcee in Genome Data Viewer
Location:
1q22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127376311..127399551)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117964576..117987779)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (125229487..125252692)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FANCD2 and FANCI associated nuclease 1 Neighboring gene M-phase phosphoprotein 10 Neighboring gene uncharacterized LOC134483612 Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene uncharacterized LOC120097338

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome. Bobik TA, et al. J Biol Chem, 2001 Oct 5. PMID 11481338
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonyl-CoA epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylmalonyl-CoA epimerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-methylmalonyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methylmalonyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
methylmalonyl-CoA epimerase, mitochondrial
NP_001099811.1
XP_038964730.1
XP_038964737.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106341.1 → NP_001099811.1  methylmalonyl-CoA epimerase, mitochondrial

    See identical proteins and their annotated locations for NP_001099811.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473980
    UniProtKB/TrEMBL
    A0A8I6AMQ5, A6JBL4
    Related
    ENSRNOP00000021884.7, ENSRNOT00000021884.8
    Conserved Domains (1) summary
    TIGR03081
    Location:49 → 177
    metmalonyl_epim; methylmalonyl-CoA epimerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    127376311..127399551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108802.2 → XP_038964730.1  methylmalonyl-CoA epimerase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A417, A6JBL6
    Conserved Domains (1) summary
    cl14632
    Location:49 → 128
    VOC; vicinal oxygen chelate (VOC) family

  2. XM_039108809.2 → XP_038964737.1  methylmalonyl-CoA epimerase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6JBL5
    Conserved Domains (1) summary
    cl14632
    Location:49 → 123
    VOC; vicinal oxygen chelate (VOC) family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools