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Cnnm2 cyclin and CBS domain divalent metal cation transport mediator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294014, updated on 2-Nov-2024

Summary

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Official Symbol
Cnnm2provided by RGD
Official Full Name
cyclin and CBS domain divalent metal cation transport mediator 2provided by RGD
Primary source
RGD:1308162
See related
EnsemblRapid:ENSRNOG00000020113 AllianceGenome:RGD:1308162
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity and magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis. Predicted to act upstream of or within magnesium ion transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 118.1), Brain (RPKM 58.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cnnm2 in Genome Data Viewer
Location:
1q54
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255585063..255709455)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245643682..245769542)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266530421..266651292)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene arsenite methyltransferase Neighboring gene uncharacterized LOC134484091 Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene uncharacterized LOC134484086 Neighboring gene transfer RNA arginine (anticodon UCU) 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter. Hirata Y, et al. J Biol Chem, 2014 May 23. PMID 24706765, Free PMC Article
  2. CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Stuiver M, et al. Am J Hum Genet, 2011 Mar 11. PMID 21397062, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in magnesium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metal transporter CNNM2
Names
ancient conserved domain-containing protein 2
cyclin-M2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011942.1 → NP_001011942.1  metal transporter CNNM2

    See identical proteins and their annotated locations for NP_001011942.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085930
    UniProtKB/Swiss-Prot
    Q5U2P1
    Related
    ENSRNOP00000051583.2, ENSRNOT00000054699.4
    Conserved Domains (2) summary
    cd04590
    Location:470 → 575
    CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
    pfam01595
    Location:257 → 431
    DUF21; Domain of unknown function DUF21

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255585063..255709455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231471.5 → XP_006231533.1  metal transporter CNNM2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZS9
    Conserved Domains (2) summary
    cd04590
    Location:470 → 575
    CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
    pfam01595
    Location:257 → 431
    DUF21; Domain of unknown function DUF21

RNA

  1. XR_005504350.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2P1.1 GenPept UniProtKB/Swiss-Prot:Q5U2P1

Gene LinkOut

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