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Asgr2 asialoglycoprotein receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29403, updated on 2-Nov-2024

Summary

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Official Symbol
Asgr2provided by RGD
Official Full Name
asialoglycoprotein receptor 2provided by RGD
Primary source
RGD:2161
See related
EnsemblRapid:ENSRNOG00000030726 AllianceGenome:RGD:2161
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable D-mannose binding activity; fucose binding activity; and pattern recognition receptor activity. Involved in bone mineralization. Predicted to be located in endoplasmic reticulum quality control compartment and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane. Orthologous to human ASGR2 (asialoglycoprotein receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 897.1) and Heart (RPKM 34.7) See more
Orthologs
human mouse all
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Genomic context

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See Asgr2 in Genome Data Viewer
Location:
10q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55320082..55333294)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54821407..54834624)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56710446..56723608)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon AGU) 28 Neighboring gene SEC61 translocon subunit gamma like 5 Neighboring gene C-type lectin domain containing 10A Neighboring gene solute carrier family 16, member 13 Neighboring gene solute carrier family 16, member 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats. Alam I, et al. Funct Integr Genomics, 2010 Mar. PMID 19841953, Free PMC Article
  2. Molecular cloning of rat sperm galactosyl receptor, a C-type lectin with in vitro egg binding activity. Rivkin E, et al. Mol Reprod Dev, 2000 Jul. PMID 10862008
  3. Primary structure of the rat liver asialoglycoprotein receptor. Structural evidence for multiple polypeptide species. Drickamer K, et al. J Biol Chem, 1984 Jan 25. PMID 6319386
  4. Major and minor forms of the rat liver asialoglycoprotein receptor are independent galactose-binding proteins. Primary structure and glycosylation heterogeneity of minor receptor forms. Halberg DF, et al. J Biol Chem, 1987 Jul 15. PMID 3597443
  5. Identification and characterization of cDNA clones encoding two homologous proteins that are part of the asialoglycoprotein receptor. McPhaul M, et al. Mol Cell Biol, 1987 May. PMID 3600647, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC108546

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bone mineralization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum quality control compartment ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
asialoglycoprotein receptor 2
Names
ASGP-R 2
ASGPR 2
HL-2
RHL-2
hepatic lectin 2, RHL2
hepatic lectin R2/3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017189.3 → NP_058885.1  asialoglycoprotein receptor 2

    See identical proteins and their annotated locations for NP_058885.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P08290, Q5M8C9
    UniProtKB/TrEMBL
    A6HG21
    Conserved Domains (2) summary
    cd03590
    Location:170 → 295
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:29 → 162
    Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55320082..55333294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246676.5 → XP_006246738.1  asialoglycoprotein receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006246738.1

    UniProtKB/Swiss-Prot
    P08290, Q5M8C9
    UniProtKB/TrEMBL
    A6HG21
    Related
    ENSRNOP00000060474.1, ENSRNOT00000065370.5
    Conserved Domains (2) summary
    cd03590
    Location:170 → 295
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:29 → 162
    Lectin_N; Hepatic lectin, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08290.4 GenPept UniProtKB/Swiss-Prot:P08290

Gene LinkOut

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