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Pank1 pantothenate kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294088, updated on 10-Jul-2024

Summary

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Official Symbol
Pank1provided by RGD
Official Full Name
pantothenate kinase 1provided by RGD
Primary source
RGD:1304677
See related
EnsemblRapid:ENSRNOG00000018944 AllianceGenome:RGD:1304677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable acetyl-CoA binding activity; pantothenate kinase activity; and protein homodimerization activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cell periphery and recycling endosome. Predicted to be part of clathrin coat. Predicted to be active in cytosol and nucleus. Orthologous to human PANK1 (pantothenate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 178.0), Kidney (RPKM 150.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pank1 in Genome Data Viewer
Location:
1q53
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241737371..241808126, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (232324718..232395445, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (253115400..253189643, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 16, member 12 Neighboring gene uncharacterized LOC134485224 Neighboring gene microRNA 107 Neighboring gene uncharacterized LOC102549070 Neighboring gene kinesin family member 20B Neighboring gene glutamyl-tRNA synthetase 2-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes. Rock CO, et al. Gene, 2002 May 29. PMID 12095677
  2. Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state. Leonardi R, et al. PLoS One, 2010 Jun 14. PMID 20559429, Free PMC Article
  3. The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha) gene, are localized on mouse chromosome 5. Nishimura H, et al. Gene, 2002 May 29. PMID 12095680
  4. Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters. Zhang YM, et al. J Biol Chem, 2005 Sep 23. PMID 16040613
  5. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. Hong BS, et al. J Biol Chem, 2007 Sep 21. PMID 17631502

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA binding ISO
Inferred from Sequence Orthology
more info
  
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pantothenate kinase 1
NP_001099843.1
XP_006231338.1
XP_006231339.1
XP_006231340.1
XP_038965184.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106373.3 → NP_001099843.1  pantothenate kinase 1

    See identical proteins and their annotated locations for NP_001099843.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I139, A6I140, D3ZWD3
    Related
    ENSRNOP00000063874.1, ENSRNOT00000067822.4
    Conserved Domains (1) summary
    pfam03630
    Location:14 → 362
    Fumble

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    241737371..241808126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231277.5 → XP_006231339.1  pantothenate kinase 1 isoform X2

    Conserved Domains (1) summary
    pfam03630
    Location:191 → 480
    Fumble; Fumble

  2. XM_006231276.4 → XP_006231338.1  pantothenate kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUU2
    Related
    ENSRNOP00000082596.1, ENSRNOT00000100218.2
    Conserved Domains (1) summary
    pfam03630
    Location:191 → 539
    Fumble; Fumble

  3. XM_039109256.2 → XP_038965184.1  pantothenate kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6G9G6
    Related
    ENSRNOP00000083785.1, ENSRNOT00000096368.2
    Conserved Domains (1) summary
    pfam03630
    Location:25 → 257
    Fumble

  4. XM_006231278.5 → XP_006231340.1  pantothenate kinase 1 isoform X3

    UniProtKB/TrEMBL
    A6I139
    Conserved Domains (1) summary
    pfam03630
    Location:1 → 347
    Fumble
Nucleotide Protein Strain
Heading Accession and Version

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