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Akt3 AKT serine/threonine kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29414, updated on 2-Nov-2024

Summary

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Official Symbol
Akt3provided by RGD
Official Full Name
AKT serine/threonine kinase 3provided by RGD
Primary source
RGD:62390
See related
EnsemblRapid:ENSRNOG00000021497 AllianceGenome:RGD:62390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pkbg
Summary
Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within cellular response to insulin stimulus and positive regulation of sodium ion transport. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 538.7), Thymus (RPKM 188.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akt3 in Genome Data Viewer
Location:
13q25
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (91475839..91758060, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (88943708..89225831, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (95076308..95348913, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phospholipase D family, member 5 Neighboring gene centrosomal protein 170 Neighboring gene microRNA 350 Neighboring gene SHH signaling and ciliogenesis regulator SDCCAG8 Neighboring gene uncharacterized LOC134481601 Neighboring gene uncharacterized LOC134481600 Neighboring gene uncharacterized LOC134481599 Neighboring gene ribosomal protein L30-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures. Campion TJ 3rd, et al. Exp Neurol, 2022 Mar. PMID 34953897
  2. Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer. Al-Saad S, et al. Anticancer Res, 2009 Oct. PMID 19846969
  3. The use of protein array to identify targetable receptor tyrosine kinases for treatment of human colon cancer. Morishita A, et al. Int J Oncol, 2010 Oct. PMID 20811704
  4. Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer. Lavender NA, et al. BMC Med Genomics, 2012 Apr 30. PMID 22546513, Free PMC Article
  5. Energy balance, polymorphisms in the mTOR pathway, and renal cell carcinoma risk. Shu X, et al. J Natl Cancer Inst, 2013 Mar 20. PMID 23378641, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS.
    Title: RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS.
  2. Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.
    Title: Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.
  3. MiR-22-3p and miR-29a-3p synergistically inhibit hepatic stellate cell activation by targeting AKT3.
    Title: MiR-22-3p and miR-29a-3p synergistically inhibit hepatic stellate cell activation by targeting AKT3.
  4. MiR-20b-5p modulates inflammation, apoptosis and angiogenesis in severe acute pancreatitis through autophagy by targeting AKT3.
    Title: MiR-20b-5p modulates inflammation, apoptosis and angiogenesis in severe acute pancreatitis through autophagy by targeting AKT3.
  5. Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures.
    Title: Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures.
  6. Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats.
    Title: Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats.
  7. The overexpressed miR-150 repressed the level of AKT3 and simultaneously alleviated mechanical and thermal hyperalgesia in a rat model of neuropathic pain.
    Title: Effects of miR-150 on neuropathic pain process via targeting AKT3.
  8. Suggest that when cardiomyocytes incur oxidative stress under diabetic conditions, it subsequently activates the PI3Kgamma/Akt cell-signaling pathway and further increases HMGB1 expression.
    Title: Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment.
  9. BAFF/BAFF-R involved in autoantibody production in rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
    Title: BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
  10. EGF but not insulin specifically upregulated Akt 2 and 3.
    Title: Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in brain morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of artery morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of artery morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell size IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
RAC-gamma serine/threonine-protein kinase
Names
AKT3 kinase
PKB gamma
RAC-PK-gamma
protein kinase Akt-3
protein kinase B, gamma
thymoma viral proto-oncogene 3
v-akt murine thymoma viral oncogene 3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
NP_113763.2
XP_038946556.1
XP_038946557.1
XP_038946558.1
XP_038946559.1
XP_038946560.1
XP_038946561.1
XP_038946562.1
XP_038946563.1
XP_038946564.1
XP_038946565.1
XP_063128274.1
XP_063128275.1
XP_063128276.1
XP_063128277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429654.1 → NP_001416583.1  RAC-gamma serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2JXD7

  2. NM_001429655.1 → NP_001416584.1  RAC-gamma serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2JXD7

  3. NM_031575.2 → NP_113763.2  RAC-gamma serine/threonine-protein kinase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q63484
    UniProtKB/TrEMBL
    A0A0G2JXD7
    Related
    ENSRNOP00000070231.3, ENSRNOT00000085648.3
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    91475839..91758060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090632.2 → XP_038946560.1  RAC-gamma serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    A6JGD0
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:152 → 419
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039090633.2 → XP_038946561.1  RAC-gamma serine/threonine-protein kinase isoform X5

    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

  3. XM_039090628.2 → XP_038946556.1  RAC-gamma serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A6JGD0
    Conserved Domains (2) summary
    cd01241
    Location:4 → 133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:175 → 442
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039090631.2 → XP_038946559.1  RAC-gamma serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    F1M6A8
    Related
    ENSRNOP00000054688.6, ENSRNOT00000057879.6
    Conserved Domains (2) summary
    cd01241
    Location:4 → 133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05571
    Location:175 → 474
    STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

  5. XM_039090630.2 → XP_038946558.1  RAC-gamma serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    Q63484
    Conserved Domains (2) summary
    cd01241
    Location:4 → 133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:155 → 502
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

  6. XM_063272204.1 → XP_063128274.1  RAC-gamma serine/threonine-protein kinase isoform X5

  7. XM_039090629.2 → XP_038946557.1  RAC-gamma serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A6JGD0
    Conserved Domains (2) summary
    cd01241
    Location:4 → 133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:175 → 442
    PKc_like; Protein Kinases, catalytic domain

  8. XM_039090637.2 → XP_038946565.1  RAC-gamma serine/threonine-protein kinase isoform X8

    UniProtKB/TrEMBL
    A6JGD0
    Conserved Domains (2) summary
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:91 → 358
    PKc_like; Protein Kinases, catalytic domain

  9. XM_063272205.1 → XP_063128275.1  RAC-gamma serine/threonine-protein kinase isoform X8

  10. XM_039090634.2 → XP_038946562.1  RAC-gamma serine/threonine-protein kinase isoform X6

    UniProtKB/TrEMBL
    A6JGD0
    Conserved Domains (2) summary
    cd01241
    Location:7 → 105
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:147 → 414
    PKc_like; Protein Kinases, catalytic domain

  11. XM_063272206.1 → XP_063128276.1  RAC-gamma serine/threonine-protein kinase isoform X8

  12. XM_039090635.1 → XP_038946563.1  RAC-gamma serine/threonine-protein kinase isoform X7

    UniProtKB/TrEMBL
    A6JGD0
    Related
    ENSRNOP00000106081.1, ENSRNOT00000136405.1
    Conserved Domains (2) summary
    cl17171
    Location:18 → 71
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:113 → 380
    PKc_like; Protein Kinases, catalytic domain

  13. XM_063272207.1 → XP_063128277.1  RAC-gamma serine/threonine-protein kinase isoform X10

  14. XM_039090636.2 → XP_038946564.1  RAC-gamma serine/threonine-protein kinase isoform X9

    Conserved Domains (2) summary
    cd01241
    Location:4 → 133
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:175 → 339
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63484.2 GenPept UniProtKB/Swiss-Prot:Q63484

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