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Ppp1r11 protein phosphatase 1, regulatory (inhibitor) subunit 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294207, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp1r11provided by RGD
Official Full Name
protein phosphatase 1, regulatory (inhibitor) subunit 11provided by RGD
Primary source
RGD:1303163
See related
EnsemblRapid:ENSRNOG00000082306 AllianceGenome:RGD:1303163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HCGV; Tctex5
Summary
Predicted to enable protein phosphatase 1 binding activity; protein serine/threonine phosphatase inhibitor activity; and ubiquitin protein ligase activity. Predicted to be involved in defense response to Gram-positive bacterium; negative regulation of cytokine production; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 160.0), Kidney (RPKM 155.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r11 in Genome Data Viewer
Location:
20p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (1606583..1610090)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (1601350..1604857)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (2094931..2098438)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RT1 class I, locus M6, gene 2 Neighboring gene ZNRD1 antisense RNA 1 Neighboring gene RNA polymerase I subunit H Neighboring gene ring finger protein 39 Neighboring gene uncharacterized LOC102554813 Neighboring gene tripartite motif-containing 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related. Cheng L, et al. PLoS One, 2009. PMID 19300506, Free PMC Article
  2. Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes. Coriton O, et al. Mamm Genome, 2000 Dec. PMID 11130983
  3. Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. Zhang J, et al. Biochemistry, 1998 Nov 24. PMID 9843442
  4. RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. McKelvey AC, et al. Elife, 2016 Nov 2. PMID 27805901, Free PMC Article
  5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94346

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase PPP1R11
Names
protein phosphatase 1 regulatory subunit 11
t-complex testis expressed-5
NP_997707.2
XP_006255932.1
XP_038954399.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212542.3 → NP_997707.2  E3 ubiquitin-protein ligase PPP1R11

    See identical proteins and their annotated locations for NP_997707.2

    Status: VALIDATED

    Source sequence(s)
    BC079252, CX571132, EX488885, FM088354
    UniProtKB/Swiss-Prot
    Q6AXZ8, Q6MFY6
    UniProtKB/TrEMBL
    A6KR78
    Related
    ENSRNOP00000103917.1, ENSRNOT00000151562.1
    Conserved Domains (1) summary
    pfam07491
    Location:30 → 72
    PPI_Ypi1; Protein phosphatase inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    1606583..1610090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098471.2 → XP_038954399.1  E3 ubiquitin-protein ligase PPP1R11 isoform X1

    Conserved Domains (1) summary
    pfam07491
    Location:10 → 52
    PPI_Ypi1; Protein phosphatase inhibitor

  2. XM_006255870.3 → XP_006255932.1  E3 ubiquitin-protein ligase PPP1R11 isoform X2

    Conserved Domains (1) summary
    pfam07491
    Location:9 → 51
    PPI_Ypi1; Protein phosphatase inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MFY6.2 GenPept UniProtKB/Swiss-Prot:Q6MFY6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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