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Ddah2 DDAH family member 2, ADMA-independent [ Rattus norvegicus (Norway rat) ]

Gene ID: 294239, updated on 2-Nov-2024

Summary

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Official Symbol
Ddah2provided by RGD
Official Full Name
DDAH family member 2, ADMA-independentprovided by RGD
Primary source
RGD:1302955
See related
EnsemblRapid:ENSRNOG00000000842 AllianceGenome:RGD:1302955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in mitochondrion. Orthologous to human DDAH2 (DDAH family member 2, ADMA-independent). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 173.3), Kidney (RPKM 150.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddah2 in Genome Data Viewer
Location:
20p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3766115..3769161, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3761460..3764718, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5049260..5052573)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene chloride intracellular channel 1 Neighboring gene U6 spliceosomal RNA Neighboring gene mutS homolog 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway. Zhou R, et al. Cardiovasc Ther, 2017 Apr. PMID 27957828
  2. Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2. Wu Y, et al. J Cardiovasc Pharmacol Ther, 2016 Nov. PMID 26911182
  3. The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus. Zheng J, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Aug. PMID 23702602
  4. Regulation of myometrial contractivity during pregnancy in the rat: potential role for DDAH. Ito E, et al. Mol Hum Reprod, 2009 Aug. PMID 19528264
  5. Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Wang D, et al. Circ Res, 2007 Sep 14. PMID 17673667

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Higher levels of asymmetric dimethylarginine are associated with lower DDAH2 and higher PRMT1 in LPS-induced endometritis rat model.
    Title: Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
  2. Suppression of DDAH2 expression might account for, at least partially, the vascular endothelial dysfunction in hyperlipidemia, and nmMLC20 plays a role in suppression of DDAH2 expression in a phosphorylation-dependent manner.
    Title: Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2.
  3. Low-dose rosuvastatin exerted cardioprotective effects on isoproterenol-induced heart failure in rats by modulating DDAH-ADMA-NO pathway.
    Title: Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway.
  4. findings suggested that in the development of type 2 diabetes mellitus, local DDAH-2 in adipocytes might play an important role in regulating insulin sensitivity
    Title: The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus.
  5. The DDAH/asymmetric dimethylarginine pathway participates in the pathogenesis of rheumatoid arthritis and may be mediated by cortistatin.
    Title: Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
  6. downregulation of DDAH2 and eNOS induced endothelial dysfunction in sinoaortic-denervated
    Title: Down-regulation of DDAH2 and eNOS induces endothelial dysfunction in sinoaortic-denervated rats.
  7. Cerebral enzymatic activities, mRNA and protein expression of arginase and DDAH were determined in African trypanosomiasis model of rat.
    Title: Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness.
  8. In healthy hearts, DDAH I is absent and DDAH II is localized to endothelium and endocardium, with a similar distribution to that of eNOS. The levels and activity of DDAH I and DDAH II are increased following myocardial infarction.
    Title: Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction.
  9. Results suggest that alterations in DDAH-2/Nos inhibitors/NO-dependent cyclic GMP/ET-1 pathway are possibly involved in maintaining myometrial quiescence during gestation and controlling delivery at term.
    Title: Regulation of myometrial contractivity during pregnancy in the rat: potential role for DDAH.
  10. CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor.
    Title: AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105993

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables dimethylargininase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in citrulline metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative hydrolase DDAH2
Names
DDAH-2
DDAHII
dimethylargininase-2
dimethylarginine dimethylaminohydrolase 2
inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
inactive dimethylarginine dimethylaminohydrolase 2
n(G),N(G)-dimethylarginine dimethylaminohydrolase 2
NP_001159408.1
NP_997697.1
XP_008770937.1
XP_063135070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165936.1 → NP_001159408.1  putative hydrolase DDAH2

    See identical proteins and their annotated locations for NP_001159408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC097930, EV770973
    UniProtKB/Swiss-Prot
    Q6MG60
    UniProtKB/TrEMBL
    A6KTR6
    Conserved Domains (1) summary
    cl19186
    Location:62 → 277
    Amidinotransf; Amidinotransferase

  2. NM_212532.2 → NP_997697.1  putative hydrolase DDAH2

    See identical proteins and their annotated locations for NP_997697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC097930, CO385374
    UniProtKB/Swiss-Prot
    Q6MG60
    UniProtKB/TrEMBL
    A6KTR6
    Related
    ENSRNOP00000069121.1, ENSRNOT00000088251.4
    Conserved Domains (1) summary
    cl19186
    Location:62 → 277
    Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3766115..3769161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772715.4 → XP_008770937.1  putative hydrolase DDAH2 isoform X2

    Conserved Domains (1) summary
    cl19186
    Location:62 → 166
    Amidinotransf; Amidinotransferase

  2. XM_063279000.1 → XP_063135070.1  putative hydrolase DDAH2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MG60.1 GenPept UniProtKB/Swiss-Prot:Q6MG60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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