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Brd2 bromodomain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294276, updated on 10-Oct-2024

Summary

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Symbol
Brd2provided by RGD
Full Name
bromodomain containing 2provided by RGD
Primary source
RGD:1303324
See related
EnsemblRapid:ENSRNOG00000000461 AllianceGenome:RGD:1303324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ring3
Summary
Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in nucleosome assembly; protein phosphorylation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 337.6), Testes (RPKM 264.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Brd2 in Genome Data Viewer
Location:
20p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4728282..4737286)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4727078..4735389)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3910555..3921074, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RT1 class II, locus DMa Neighboring gene bromodomain containing 2 like Neighboring gene RT1 class II, locus DOa Neighboring gene RT1 class II, locus Ha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Segura MF, et al. Cancer Res, 2013 Oct 15. PMID 23950209, Free PMC Article
  2. Brd2 disruption in mice causes severe obesity without Type 2 diabetes. Wang F, et al. Biochem J, 2009 Dec 14. PMID 19883376, Free PMC Article
  3. Association of BRD2 polymorphisms with photoparoxysmal response. Lorenz S, et al. Neurosci Lett, 2006 May 29. PMID 16516380
  4. Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia. Crowley T, et al. Brain Res Dev Brain Res, 2004 Apr 19. PMID 15063089
  5. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Greenwald RJ, et al. Blood, 2004 Feb 15. PMID 14563639, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylation-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin looping ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin looping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of T-helper 17 cell lineage commitment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bromodomain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212495.1 → NP_997660.1  bromodomain-containing protein 2

    See identical proteins and their annotated locations for NP_997660.1

    Status: VALIDATED

    Source sequence(s)
    BX883042
    UniProtKB/Swiss-Prot
    Q6MGA9
    UniProtKB/TrEMBL
    A0A8I5ZYL9, A6JJF0
    Conserved Domains (4) summary
    cd05497
    Location:73 → 179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348 → 449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:215 → 332
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:639 → 701
    BET; Bromodomain extra-terminal - transcription regulation

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4728282..4737286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279018.1 → XP_063135088.1  bromodomain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6MGA9
    UniProtKB/TrEMBL
    A6JJF0

  2. XM_017601578.3 → XP_017457067.1  bromodomain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6MGA9
    UniProtKB/TrEMBL
    A0A8I5ZYL9, A6JJF0
    Related
    ENSRNOP00000098184.1, ENSRNOT00000120531.2
    Conserved Domains (4) summary
    cd05497
    Location:73 → 179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348 → 449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:215 → 332
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:639 → 701
    BET; Bromodomain extra-terminal - transcription regulation

  3. XM_039098498.2 → XP_038954426.1  bromodomain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    cd05497
    Location:73 → 179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:215 → 332
    PHA03247; large tegument protein UL36; Provisional
    cl02556
    Location:348 → 400
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  4. XM_008772772.4 → XP_008770994.1  bromodomain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_008770994.1

    UniProtKB/TrEMBL
    A0A8I5ZYL9
    Related
    ENSRNOP00000082798.3, ENSRNOT00000060194.7
    Conserved Domains (3) summary
    cd05497
    Location:27 → 133
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:302 → 403
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:593 → 657
    BET; Bromodomain extra-terminal - transcription regulation

  5. XM_063279019.1 → XP_063135089.1  bromodomain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K1Z8
    Related
    ENSRNOP00000072049.4, ENSRNOT00000080585.4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MGA9.1 GenPept UniProtKB/Swiss-Prot:Q6MGA9

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