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Pald1 phosphatase domain containing, paladin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294508, updated on 17-Aug-2024

Summary

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Official Symbol
Pald1provided by RGD
Official Full Name
phosphatase domain containing, paladin 1provided by RGD
Primary source
RGD:1305933
See related
EnsemblRapid:ENSRNOG00000000561 AllianceGenome:RGD:1305933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pald
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PALD1 (phosphatase domain containing paladin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 174.4), Lung (RPKM 103.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pald1 in Genome Data Viewer
Location:
20q11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (29812650..29877733, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29269814..29334850, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (30938901..30983907, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 14 Neighboring gene perforin 1 Neighboring gene nodal growth differentiation factor Neighboring gene eukaryotic translation initiation factor 4E binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis. Gungor-Ordueri NE, et al. Am J Physiol Endocrinol Metab, 2014 Nov 1. PMID 25159326, Free PMC Article
  2. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. Wallgard E, et al. Dev Dyn, 2012 Apr. PMID 22354871
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112800

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
paladin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034128.2 → NP_001029300.2  paladin

    See identical proteins and their annotated locations for NP_001029300.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A6K3Z5, D3ZCT5
    Related
    ENSRNOP00000062593.1, ENSRNOT00000066794.5
    Conserved Domains (2) summary
    cd17659
    Location:92 → 383
    PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
    cl28904
    Location:477 → 734
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    29812650..29877733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098611.2 → XP_038954539.1  paladin isoform X1

    UniProtKB/TrEMBL
    A6K3Z5, D3ZCT5
    Conserved Domains (2) summary
    cd17659
    Location:92 → 383
    PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
    cl28904
    Location:477 → 734
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_039098612.2 → XP_038954540.1  paladin isoform X1

    UniProtKB/TrEMBL
    A6K3Z5, D3ZCT5
    Conserved Domains (2) summary
    cd17659
    Location:92 → 383
    PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
    cl28904
    Location:477 → 734
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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