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Ascc1 activating signal cointegrator 1 complex subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294512, updated on 2-Nov-2024

Summary

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Symbol
Ascc1provided by RGD
Full Name
activating signal cointegrator 1 complex subunit 1provided by RGD
Primary source
RGD:1359255
See related
EnsemblRapid:ENSRNOG00000056647 AllianceGenome:RGD:1359255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Asc-1; CGI-18
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in neuromuscular junction. Predicted to be part of DNA repair complex and transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human ASCC1 (activating signal cointegrator 1 complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 92.9), Adrenal (RPKM 87.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ascc1 in Genome Data Viewer
Location:
20q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (28484044..28574195)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27941053..28031272)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (29558330..29648899)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483913 Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene cytochrome c oxidase subunit 5B, pseudogene 2 Neighboring gene uncharacterized LOC134483914 Neighboring gene SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 Neighboring gene ribosomal protein S29, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94577

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA repair complex ISO
Inferred from Sequence Orthology
more info
  
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
activating signal cointegrator 1 complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007632.2 → NP_001007633.1  activating signal cointegrator 1 complex subunit 1

    See identical proteins and their annotated locations for NP_001007633.1

    Status: VALIDATED

    Source sequence(s)
    BP504504, CB742862, CK357599
    UniProtKB/TrEMBL
    A0A8I5ZMZ0, A6K3W2, G3V619
    Related
    ENSRNOP00000079571.1, ENSRNOT00000118854.2
    Conserved Domains (3) summary
    PLN00108
    Location:128 → 355
    PLN00108; unknown protein; Provisional
    cd02394
    Location:61 → 119
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:132 → 355
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    28484044..28574195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098614.2 → XP_038954542.1  activating signal cointegrator 1 complex subunit 1 isoform X4

    Conserved Domains (2) summary
    pfam10469
    Location:165 → 281
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    cd22419
    Location:91 → 156
    KH-I_ASCC1; type I K homology (KH) RNA-binding domain found in activating signal cointegrator 1 complex subunit 1 (ASCC1) and similar proteins

  2. XM_006256404.4 → XP_006256466.1  activating signal cointegrator 1 complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMZ0
    Conserved Domains (3) summary
    PLN00108
    Location:161 → 388
    PLN00108; unknown protein; Provisional
    cd02394
    Location:94 → 152
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:165 → 388
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  3. XM_006256405.4 → XP_006256467.1  activating signal cointegrator 1 complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZMZ0
    Conserved Domains (3) summary
    PLN00108
    Location:160 → 387
    PLN00108; unknown protein; Provisional
    cd02394
    Location:93 → 151
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:164 → 387
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  4. XM_063279072.1 → XP_063135142.1  activating signal cointegrator 1 complex subunit 1 isoform X5

  5. XM_006256407.5 → XP_006256469.2  activating signal cointegrator 1 complex subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_006256469.2

    UniProtKB/TrEMBL
    A0A8I5ZMZ0, A6K3W2, G3V619
    Related
    ENSRNOP00000075634.2, ENSRNOT00000085229.3
    Conserved Domains (3) summary
    PLN00108
    Location:128 → 355
    PLN00108; unknown protein; Provisional
    cd02394
    Location:61 → 119
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:132 → 355
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  6. XM_063279073.1 → XP_063135143.1  activating signal cointegrator 1 complex subunit 1 isoform X5

  7. XM_006256409.4 → XP_006256471.1  activating signal cointegrator 1 complex subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_006256471.1

    UniProtKB/TrEMBL
    A0A8I5ZMZ0, A6K3W2, G3V619
    Conserved Domains (3) summary
    PLN00108
    Location:128 → 355
    PLN00108; unknown protein; Provisional
    cd02394
    Location:61 → 119
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:132 → 355
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  8. XM_008772881.4 → XP_008771103.1  activating signal cointegrator 1 complex subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_008771103.1

    UniProtKB/TrEMBL
    A0A8I5ZMZ0, A6K3W2, G3V619
    Conserved Domains (3) summary
    PLN00108
    Location:128 → 355
    PLN00108; unknown protein; Provisional
    cd02394
    Location:61 → 119
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:132 → 355
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  9. XM_006256410.5 → XP_006256472.1  activating signal cointegrator 1 complex subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_006256472.1

    UniProtKB/TrEMBL
    A0A8I5ZMZ0, A6K3W2, G3V619
    Conserved Domains (3) summary
    PLN00108
    Location:128 → 355
    PLN00108; unknown protein; Provisional
    cd02394
    Location:61 → 119
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:132 → 355
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  10. XM_006256408.5 → XP_006256470.1  activating signal cointegrator 1 complex subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_006256470.1

    UniProtKB/TrEMBL
    A0A8I5ZMZ0, A6K3W2, G3V619
    Conserved Domains (3) summary
    PLN00108
    Location:128 → 355
    PLN00108; unknown protein; Provisional
    cd02394
    Location:61 → 119
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:132 → 355
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
Nucleotide Protein Strain
Heading Accession and Version

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