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Cep57l1 centrosomal protein 57-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294519, updated on 10-Jul-2024

Summary

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Official Symbol
Cep57l1provided by RGD
Official Full Name
centrosomal protein 57-like 1provided by RGD
Primary source
RGD:1311358
See related
EnsemblRapid:ENSRNOG00000000303 AllianceGenome:RGD:1311358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
cep57R
Summary
Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Predicted to be active in centrosome. Orthologous to human CEP57L1 (centrosomal protein 57 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 77.2), Adrenal (RPKM 47.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep57l1 in Genome Data Viewer
Location:
20q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (46820350..46876911, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (45238039..45294575, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (46610144..46666780, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483931 Neighboring gene coiled-coil domain containing 162 Neighboring gene uncharacterized LOC120098881 Neighboring gene sestrin 1 Neighboring gene armadillo repeat containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein CEP57L1
Names
centrosomal protein 57kDa-like protein 1
centrosomal protein of 57 kDa-related protein
cep57-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017448.2 → NP_001017448.2  centrosomal protein CEP57L1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A0H2UH91, A6K701
    Related
    ENSRNOP00000089494.1, ENSRNOT00000111438.2
    Conserved Domains (2) summary
    pfam06657
    Location:301 → 372
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:66 → 243
    Cep57_CLD; Centrosome localization domain of Cep57

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    46820350..46876911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098619.2 → XP_038954547.1  centrosomal protein CEP57L1 isoform X6

    Conserved Domains (1) summary
    pfam14073
    Location:91 → 268
    Cep57_CLD; Centrosome localization domain of Cep57

  2. XM_063279078.1 → XP_063135148.1  centrosomal protein CEP57L1 isoform X7

  3. XM_063279076.1 → XP_063135146.1  centrosomal protein CEP57L1 isoform X4

    UniProtKB/TrEMBL
    A6K701

  4. XM_006256565.4 → XP_006256627.1  centrosomal protein CEP57L1 isoform X3

    See identical proteins and their annotated locations for XP_006256627.1

    UniProtKB/Swiss-Prot
    Q6AXZ4
    UniProtKB/TrEMBL
    A6K701
    Conserved Domains (2) summary
    pfam06657
    Location:284 → 357
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  5. XM_006256563.5 → XP_006256625.1  centrosomal protein CEP57L1 isoform X2

    UniProtKB/TrEMBL
    A6K701
    Conserved Domains (4) summary
    pfam06657
    Location:310 → 381
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:91 → 252
    Cep57_CLD; Centrosome localization domain of Cep57
    cd16269
    Location:178 → 189
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:90 → 206
    GBP_C; Guanylate-binding protein, C-terminal domain

  6. XM_006256562.5 → XP_006256624.1  centrosomal protein CEP57L1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLF7, A6K701
    Related
    ENSRNOP00000090876.2, ENSRNOT00000104623.2
    Conserved Domains (2) summary
    pfam06657
    Location:326 → 397
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:91 → 268
    Cep57_CLD; Centrosome localization domain of Cep57

  7. XM_006256567.5 → XP_006256629.1  centrosomal protein CEP57L1 isoform X3

    See identical proteins and their annotated locations for XP_006256629.1

    UniProtKB/Swiss-Prot
    Q6AXZ4
    UniProtKB/TrEMBL
    A6K701
    Conserved Domains (2) summary
    pfam06657
    Location:284 → 357
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  8. XM_039098618.2 → XP_038954546.1  centrosomal protein CEP57L1 isoform X3

    UniProtKB/Swiss-Prot
    Q6AXZ4
    UniProtKB/TrEMBL
    A6K701
    Conserved Domains (2) summary
    pfam06657
    Location:284 → 357
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  9. XM_063279077.1 → XP_063135147.1  centrosomal protein CEP57L1 isoform X5

    UniProtKB/TrEMBL
    A6K701
    Related
    ENSRNOP00000084661.1, ENSRNOT00000094398.2

  10. XM_006256566.5 → XP_006256628.1  centrosomal protein CEP57L1 isoform X3

    See identical proteins and their annotated locations for XP_006256628.1

    UniProtKB/Swiss-Prot
    Q6AXZ4
    UniProtKB/TrEMBL
    A6K701
    Related
    ENSRNOP00000108566.1, ENSRNOT00000166206.1
    Conserved Domains (2) summary
    pfam06657
    Location:284 → 357
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:50 → 227
    Cep57_CLD; Centrosome localization domain of Cep57

  11. XM_039098621.2 → XP_038954549.1  centrosomal protein CEP57L1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZZL1
    Conserved Domains (2) summary
    pfam06657
    Location:150 → 223
    Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
    pfam14073
    Location:1 → 93
    Cep57_CLD; Centrosome localization domain of Cep57
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXZ4.1 GenPept UniProtKB/Swiss-Prot:Q6AXZ4

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