U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sh3rf3 SH3 domain containing ring finger 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294557, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Sh3rf3provided by RGD
Official Full Name
SH3 domain containing ring finger 3provided by RGD
Primary source
RGD:1589772
See related
EnsemblRapid:ENSRNOG00000046791 AllianceGenome:RGD:1589772
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sh3md4
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Orthologous to human SH3RF3 (SH3 domain containing ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 39.5), Brain (RPKM 23.6) and 6 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
20q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27306937..27642315)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26765278..27099261)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28355671..28720020)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ectodysplasin-A receptor Neighboring gene uncharacterized LOC103694417 Neighboring gene uncharacterized LOC134483911 Neighboring gene leucine-rich repeat-containing protein 57-like Neighboring gene uncharacterized LOC134483910 Neighboring gene septin 10 Neighboring gene sosondowah ankyrin repeat domain family member C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis. Ma CX, et al. Cell Mol Life Sci, 2023 Jan 24. PMID 36694058, Free PMC Article
  2. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. Kärkkäinen S, et al. FEBS Lett, 2010 Sep 24. PMID 20696164
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis.
    Title: Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase SH3RF3
Names
SH3 domain-containing RING finger protein 3
SH3 multiple domains 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    27306937..27642315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601803.3 → XP_017457292.1  E3 ubiquitin-protein ligase SH3RF3 isoform X1

    UniProtKB/TrEMBL
    M0R6D9
    Related
    ENSRNOP00000064987.3, ENSRNOT00000072485.5

  2. XM_039099198.2 → XP_038955126.1  E3 ubiquitin-protein ligase SH3RF3 isoform X2

    Conserved Domains (3) summary
    PHA03269
    Location:576 → 697
    PHA03269; envelope glycoprotein C; Provisional
    cd16750
    Location:48 → 93
    RING-HC_SH3RF3; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins
    cl17036
    Location:462 → 518
    SH3; Src Homology 3 domain superfamily

  3. XM_063279663.1 → XP_063135733.1  E3 ubiquitin-protein ligase SH3RF3 isoform X4

  4. XM_039099199.2 → XP_038955127.1  E3 ubiquitin-protein ligase SH3RF3 isoform X5

    UniProtKB/TrEMBL
    A6K3U1
    Conserved Domains (2) summary
    cd16750
    Location:48 → 93
    RING-HC_SH3RF3; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins
    cl17036
    Location:462 → 518
    SH3; Src Homology 3 domain superfamily

  5. XM_017601804.3 → XP_017457293.1  E3 ubiquitin-protein ligase SH3RF3 isoform X3

  6. XM_039099200.2 → XP_038955128.1  E3 ubiquitin-protein ligase SH3RF3 isoform X6

    Conserved Domains (3) summary
    cd11785
    Location:431 → 485
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    PHA03247
    Location:125 → 358
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:70 → 126
    SH3; Src Homology 3 domain superfamily

  7. XM_039099201.2 → XP_038955129.1  E3 ubiquitin-protein ligase SH3RF3 isoform X7

    Conserved Domains (3) summary
    cd11785
    Location:399 → 453
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    PHA03247
    Location:93 → 326
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:38 → 94
    SH3; Src Homology 3 domain superfamily

  8. XM_039099202.2 → XP_038955130.1  E3 ubiquitin-protein ligase SH3RF3 isoform X7

    Conserved Domains (3) summary
    cd11785
    Location:399 → 453
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    PHA03247
    Location:93 → 326
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:38 → 94
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_010061102.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools