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Gfm2 GTP dependent ribosome recycling factor mitochondrial 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294672, updated on 2-Nov-2024

Summary

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Official Symbol
Gfm2provided by RGD
Official Full Name
GTP dependent ribosome recycling factor mitochondrial 2provided by RGD
Primary source
RGD:1309854
See related
EnsemblRapid:ENSRNOG00000025285 AllianceGenome:RGD:1309854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309854
Summary
Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 138.5), Adrenal (RPKM 136.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gfm2 in Genome Data Viewer
Location:
2q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (30184063..30222811)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (28449452..28488200)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (27949195..27984045)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 pseudogene Neighboring gene family with sequence similarity 169, member A Neighboring gene NSA2 ribosome biogenesis factor Neighboring gene hexosaminidase subunit beta Neighboring gene uncharacterized LOC120100676 Neighboring gene ectodermal-neural cortex 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. Tsuboi M, et al. Mol Cell, 2009 Aug 28. PMID 19716793
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables translation elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in mitochondrial translational elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosome-releasing factor 2, mitochondrial
Names
EF-G2mt
G elongation factor, mitochondrial 2
RRF2mt
elongation factor G 2, mitochondrial
mEF-G 2
NP_001094135.1
XP_006231892.1
XP_017446189.1
XP_063137561.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100665.1 → NP_001094135.1  ribosome-releasing factor 2, mitochondrial

    See identical proteins and their annotated locations for NP_001094135.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q5BJP6
    UniProtKB/TrEMBL
    A0A0G2K1R1
    Related
    ENSRNOP00000043087.5, ENSRNOT00000052072.6
    Conserved Domains (6) summary
    cd01886
    Location:72 → 352
    EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
    PRK12739
    Location:66 → 774
    PRK12739; elongation factor G; Reviewed
    cd01693
    Location:561 → 679
    mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...
    cd03713
    Location:684 → 761
    EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...
    cd04092
    Location:367 → 448
    mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
    cd16262
    Location:485 → 560
    EFG_III; Domain III of Elongation Factor G (EFG)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    30184063..30222811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590700.2 → XP_017446189.1  ribosome-releasing factor 2, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q5BJP6
    UniProtKB/TrEMBL
    A0A8I6A4R7
    Related
    ENSRNOP00000086144.1, ENSRNOT00000113513.2

  2. XM_063281491.1 → XP_063137561.1  ribosome-releasing factor 2, mitochondrial isoform X3

    Related
    ENSRNOP00000103345.1, ENSRNOT00000166369.1

  3. XM_006231830.5 → XP_006231892.1  ribosome-releasing factor 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006231892.1

    UniProtKB/Swiss-Prot
    Q5BJP6
    UniProtKB/TrEMBL
    A0A0G2K1R1
    Related
    ENSRNOP00000071947.1, ENSRNOT00000080551.3
    Conserved Domains (6) summary
    cd01886
    Location:72 → 352
    EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
    PRK12739
    Location:66 → 774
    PRK12739; elongation factor G; Reviewed
    cd01693
    Location:561 → 679
    mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...
    cd03713
    Location:684 → 761
    EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...
    cd04092
    Location:367 → 448
    mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
    cd16262
    Location:485 → 560
    EFG_III; Domain III of Elongation Factor G (EFG)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJP6.2 GenPept UniProtKB/Swiss-Prot:Q5BJP6

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