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Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294809, updated on 10-Jul-2024

Summary

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Official Symbol
Adamts12provided by RGD
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 12provided by RGD
Primary source
RGD:1307323
See related
EnsemblRapid:ENSRNOG00000018865 AllianceGenome:RGD:1307323
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of cellular response to growth factor stimulus; protein catabolic process; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 144.1), Lung (RPKM 89.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adamts12 in Genome Data Viewer
Location:
2q16
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61759975..62054716)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (60032873..60327629)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (61039072..61340687)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100741 Neighboring gene relaxin family peptide receptor 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene threonyl-tRNA synthetase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis. Yang S, et al. Mol Med, 2023 Jul 3. PMID 37400752, Free PMC Article
  2. Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc. Yu H, et al. J Vet Med Sci, 2012 Jan. PMID 21869572
  3. Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion? Beristain AG, et al. PLoS One, 2011 Apr 11. PMID 21494557, Free PMC Article
  4. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. Llamazares M, et al. J Cell Sci, 2007 Oct 15. PMID 17895370
  5. ADAMTS-12 metalloprotease is necessary for normal inflammatory response. Moncada-Pazos A, et al. J Biol Chem, 2012 Nov 16. PMID 23019333, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis.
    Title: Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis.
  2. ADAMTS-7 and ADAMTS-12 expression were dramatically increased during disc degeneration.
    Title: Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in ossification involved in bone maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 12
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106420.4 → NP_001099890.2  A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D3ZTJ3
    Related
    ENSRNOP00000025693.6, ENSRNOT00000025693.9
    Conserved Domains (7) summary
    smart00209
    Location:549 → 600
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:250 → 457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:250 → 460
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:80 → 196
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17061
    Location:1021 → 1176
    PARM; PARM
    cl15456
    Location:519 → 680
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    61759975..62054716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101948.2 → XP_038957876.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

    Conserved Domains (7) summary
    smart00209
    Location:549 → 600
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:250 → 457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:53 → 197
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:472 → 536
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:952 → 1000
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl15456
    Location:519 → 680
    ADAM_CR; ADAM cysteine-rich
Nucleotide Protein Strain
Heading Accession and Version

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