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Marchf6 membrane associated ring-CH-type finger 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294862, updated on 10-Oct-2024

Summary

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Official Symbol
Marchf6provided by RGD
Official Full Name
membrane associated ring-CH-type finger 6provided by RGD
Primary source
RGD:1565757
See related
EnsemblRapid:ENSRNOG00000011066 AllianceGenome:RGD:1565757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
March6; RGD1310927; RGD1565757
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and ubiquitin-specific protease binding activity. Predicted to be involved in protein K48-linked ubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 377.5), Adrenal (RPKM 359.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Marchf6 in Genome Data Viewer
Location:
2q23
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (84166570..84243817, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (82455686..82532917, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (84533546..84608743, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553736 Neighboring gene rhophilin associated tail protein 1-like Neighboring gene small nucleolar RNA SNORA24 Neighboring gene uncharacterized LOC134485604 Neighboring gene carboxymethylenebutenolidase homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). Kreft SG, et al. J Biol Chem, 2006 Feb 24. PMID 16373356
  2. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. Zelcer N, et al. Mol Cell Biol, 2014 Apr. PMID 24449766, Free PMC Article
  3. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Zavacki AM, et al. Mol Cell Biol, 2009 Oct. PMID 19651899, Free PMC Article
  4. Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary. Zhang X, et al. Biol Trace Elem Res, 2016 Dec. PMID 27156111
  5. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Hassink G, et al. Biochem J, 2005 Jun 1. PMID 15673284, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis.
    Title: Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary.
  2. TEB4 interacts with and mediates loss of type 2 iodothyronine deiodinase (D2)activity, indicating that D2 ubiquitination and degradation can be tissue specific, depending on WSB-1 and TEB4 expression levels.
    Title: The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF6
Names
E3 ubiquitin-protein ligase MARCH6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
NP_001292203.1
XP_008759048.1
XP_063137600.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305274.1 → NP_001292203.1  E3 ubiquitin-protein ligase MARCHF6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6AW75
    Related
    ENSRNOP00000079950.2, ENSRNOT00000094024.2
    Conserved Domains (1) summary
    cd16702
    Location:8 → 57
    RING_CH-C4HC3_MARCH6; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH6 (MARCH6)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    84166570..84243817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760826.4 → XP_008759048.1  E3 ubiquitin-protein ligase MARCHF6 isoform X1

    See identical proteins and their annotated locations for XP_008759048.1

    UniProtKB/TrEMBL
    A0A8I6AW75, F1M1F1
    Related
    ENSRNOP00000028561.6, ENSRNOT00000028561.9
    Conserved Domains (1) summary
    cd16702
    Location:8 → 57
    RING_CH-C4HC3_MARCH6; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH6 (MARCH6)

  2. XM_063281530.1 → XP_063137600.1  E3 ubiquitin-protein ligase MARCHF6 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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