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Pcdh18 protocadherin 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295027, updated on 2-Nov-2024

Summary

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Official Symbol
Pcdh18provided by RGD
Official Full Name
protocadherin 18provided by RGD
Primary source
RGD:1305870
See related
EnsemblRapid:ENSRNOG00000009949 AllianceGenome:RGD:1305870
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in brain development and cell adhesion. Predicted to be active in plasma membrane. Orthologous to human PCDH18 (protocadherin 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 171.3), Uterus (RPKM 66.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pcdh18 in Genome Data Viewer
Location:
2q26
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (135982929..135996917, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (133831996..133845992, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (138819957..138833932, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene rho GTPase-activating protein 20-like Neighboring gene rho GTPase-activating protein 20-like Neighboring gene sterile alpha motif domain containing 3, pseudogene 1 Neighboring gene ribosomal protein L18A, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disabled-1 interacts with a novel developmentally regulated protocadherin. Homayouni R, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716507
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC188762

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protocadherin-18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100524.2 → NP_001093994.1  protocadherin-18 precursor

    See identical proteins and their annotated locations for NP_001093994.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    B5DEL4
    Related
    ENSRNOP00000013343.7, ENSRNOT00000013343.8
    Conserved Domains (2) summary
    cd11304
    Location:469 → 572
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:30 → 111
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    135982929..135996917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232322.5 → XP_006232384.1  protocadherin-18 isoform X1

    See identical proteins and their annotated locations for XP_006232384.1

    UniProtKB/TrEMBL
    A6JV49, F7EKI5
    Conserved Domains (2) summary
    cd11304
    Location:469 → 572
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:30 → 111
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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