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Spart spartin [ Rattus norvegicus (Norway rat) ]

Gene ID: 295053, updated on 10-Jul-2024

Summary

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Official Symbol
Spartprovided by RGD
Official Full Name
spartinprovided by RGD
Primary source
RGD:1305900
See related
EnsemblRapid:ENSRNOG00000014155 AllianceGenome:RGD:1305900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spg20
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in abscission; cell division; and negative regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including adipose tissue development; lipid droplet organization; and negative regulation of collateral sprouting in absence of injury. Predicted to be located in several cellular components, including lipid droplet; midbody; and mitochondrial outer membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Troyer syndrome. Orthologous to human SPART (spartin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 137.7), Muscle (RPKM 103.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spart in Genome Data Viewer
Location:
2q26
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141442770..141469388)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (139292630..139319248)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (144522382..144548968)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene cyclin A1 Neighboring gene uncharacterized LOC134485736 Neighboring gene uncharacterized LOC134485916 Neighboring gene coiled-coil domain containing 169 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 2 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis. Joshi DC, et al. PLoS One, 2011 Apr 29. PMID 21559443, Free PMC Article
  2. Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Renvoisé B, et al. Hum Mol Genet, 2012 Aug 15. PMID 22619377, Free PMC Article
  3. Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. Edwards TL, et al. Biochem J, 2009 Sep 14. PMID 19580544, Free PMC Article
  4. SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Renvoisé B, et al. Mol Biol Cell, 2010 Oct 1. PMID 20719964, Free PMC Article
  5. Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets. Urbanczyk A, et al. J Neurochem, 2011 Sep. PMID 21707618

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in abscission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of collateral sprouting in absence of injury ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid droplet organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of collateral sprouting in absence of injury ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spartin
Names
spastic paraplegia 20 (Troyer syndrome) homolog
spastic paraplegia 20, spartin (Troyer syndrome) homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106433.3 → NP_001099903.3  spartin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6JVE5
    Related
    ENSRNOP00000078817.1, ENSRNOT00000116850.2
    Conserved Domains (2) summary
    cd02679
    Location:16 → 95
    MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
    pfam06911
    Location:434 → 618
    Senescence; Senescence-associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    141442770..141469388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232367.5 → XP_006232429.2  spartin isoform X3

    UniProtKB/TrEMBL
    A6JVE5
    Conserved Domains (2) summary
    cd02679
    Location:16 → 95
    MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
    pfam06911
    Location:434 → 618
    Senescence; Senescence-associated protein

  2. XM_006232365.5 → XP_006232427.2  spartin isoform X1

    UniProtKB/TrEMBL
    A6JVE5
    Conserved Domains (2) summary
    cd02679
    Location:27 → 106
    MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
    pfam06911
    Location:445 → 629
    Senescence; Senescence-associated protein

  3. XM_006232366.5 → XP_006232428.2  spartin isoform X2

    UniProtKB/TrEMBL
    A6JVE5
    Related
    ENSRNOP00000054787.6, ENSRNOT00000057978.6
    Conserved Domains (2) summary
    cd02679
    Location:24 → 103
    MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
    pfam06911
    Location:442 → 626
    Senescence; Senescence-associated protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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