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Gmps guanine monophosphate synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 295088, updated on 10-Jul-2024

Summary

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Official Symbol
Gmpsprovided by RGD
Official Full Name
guanine monophosphate synthaseprovided by RGD
Primary source
RGD:1310063
See related
EnsemblRapid:ENSRNOG00000051151 AllianceGenome:RGD:1310063
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GMP synthase activity and enzyme binding activity. Involved in GMP biosynthetic process; response to L-cysteine; and response to xenobiotic stimulus. Located in cytosol. Biomarker of hepatocellular carcinoma. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 378.3), Heart (RPKM 362.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gmps in Genome Data Viewer
Location:
2q31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (150587824..150641564)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (148441369..148491908)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (154555967..154590662)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 3 open reading frame 33 Neighboring gene solute carrier family 33 member 1 Neighboring gene vomeronasal 2 receptor 44 Neighboring gene vomeronasal 2 receptor, 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enzymes of purine metabolism in cancer. Weber G. Clin Biochem, 1983 Feb. PMID 6861338
  2. Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin. Prajda N, et al. Biochem Pharmacol, 1988 Mar 1. PMID 3345200
  3. Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride. Jayaram HN, et al. Cancer Chemother Pharmacol, 1990. PMID 2347042
  4. Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. Hirst M, et al. J Biol Chem, 1994 Sep 23. PMID 8089153
  5. Enhanced in vitro growth of glomerular cells derived from rats with immune-mediated mesangial injury. Harendza SG, et al. Exp Nephrol, 1993 Jan-Feb. PMID 8081953

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GMP synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
  
enables GMP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GMP synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables GMP synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in GMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP salvage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to L-cysteine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthase
GMP synthetase
glutamine amidotransferase
guanine monophosphate synthetase
NP_001019925.1
XP_038957944.1
XP_038957945.1
XP_063137657.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024754.1 → NP_001019925.1  GMP synthase [glutamine-hydrolyzing]

    See identical proteins and their annotated locations for NP_001019925.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098016
    UniProtKB/Swiss-Prot
    Q4V7C6
    UniProtKB/TrEMBL
    A0A0G2K2C2
    Related
    ENSRNOP00000109550.1, ENSRNOT00000167462.1
    Conserved Domains (1) summary
    PRK00074
    Location:28 → 693
    guaA; GMP synthase; Reviewed

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    150587824..150641564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102016.2 → XP_038957944.1  GMP synthase [glutamine-hydrolyzing] isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2C2, A0A8L2R0S7
    Conserved Domains (1) summary
    PRK00074
    Location:69 → 734
    guaA; GMP synthase; Reviewed

  2. XM_063281587.1 → XP_063137657.1  GMP synthase [glutamine-hydrolyzing] isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2C2, A0A8L2R0S7

  3. XM_039102017.2 → XP_038957945.1  GMP synthase [glutamine-hydrolyzing] isoform X2

    UniProtKB/TrEMBL
    A6JVP6
    Conserved Domains (1) summary
    PRK00074
    Location:28 → 520
    guaA; GMP synthase; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7C6.1 GenPept UniProtKB/Swiss-Prot:Q4V7C6

Gene LinkOut

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Chemical Information
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Research Materials
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