Schip1 schwannomin interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Schip1provided by RGD
Official Full Name: schwannomin interacting protein 1provided by RGD
Primary source: RGD:1309962
See related: EnsemblRapid:ENSRNOG00000009276 AllianceGenome:RGD:1309962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of hippo signaling. Predicted to act upstream of or within several processes, including animal organ development; face morphogenesis; and fibroblast migration. Predicted to be located in cytosol and nuclear body. Predicted to be active in cell junction and plasma membrane. Orthologous to several human genes including SCHIP1 (schwannomin interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 123.4), Brain (RPKM 123.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (154437217..155198560)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (152127171..152888587)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (172312290..173087236, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance.
Title: CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

Submit: New GeneRIF Correction

General gene information

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Markers

AI170339 (e-PCR)
- UniSTS:250398

d2rat164 (e-PCR)
- UniSTS:121652

RH137633 (e-PCR)
- UniSTS:219720

D2Mco14 (e-PCR)
- UniSTS:239439

G44760 (e-PCR)
- UniSTS:105562

D2Mco7 (e-PCR)
- UniSTS:239221

D2Mco8 (e-PCR)
- UniSTS:239222

AU026418 (e-PCR)
- UniSTS:114299

D17S1446E (e-PCR)
- UniSTS:150485

BF403845 (e-PCR)
- UniSTS:246520

AU028121 (e-PCR)
- UniSTS:112638

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within estrogen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within luteinization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: schwannomin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100666.1 → NP_001094136.1 schwannomin-interacting protein 1

Status: VALIDATED

Source sequence(s)

BC092618, CB726734, CK366144, JAXUCZ010000002

UniProtKB/TrEMBL

F1M6Q1

Conserved Domains (2) summary

pfam10148
Location:328 → 554

SCHIP-1; Schwannomin-interacting protein 1

pfam15157
Location:4 → 97

IQCJ-SCHIP1; Fusion protein IQCJ-SCHIP1 with IQ-like motif