Padi2 peptidyl arginine deiminase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Padi2provided by RGD
Official Full Name: peptidyl arginine deiminase 2provided by RGD
Primary source: RGD:3288
See related: EnsemblRapid:ENSRNOG00000007574 AllianceGenome:RGD:3288
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pdi2
Summary: Enables protein-arginine deiminase activity. Involved in protein citrullination. Predicted to be located in transcriptionally active chromatin. Predicted to be active in cytoplasm and nucleus. Orthologous to human PADI2 (peptidyl arginine deiminase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 204.5), Brain (RPKM 97.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (158492087..158534662)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (153209053..153251632)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (159428479..159471113)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These biochemical and immunohistochemical results suggest that PAD2 might play an important role in the pathology of early Alzheimer's disease
Title: Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble Abeta(25-35) in the Alzheimer's disease model rat brain: effect of memantine.
Mechanical stretching induced PAD2 expression and consequent protein deimination.
Title: Mechanical stretching elevates peptidyl arginine deiminase 2 expression in astrocytes.
The reduced levels of deimination commensurate with reduced protein, mRNA and activity of peptidylarginine deiminase type 2 in the retina.
Title: Age-related reduction in retinal deimination levels in the F344BN rat.
This report revealed the expression of PAD2 by microglia in the prenatal cerebrum at embryonic stages E19-E21.
Title: Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain.

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General gene information

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Markers

RH132527 (e-PCR)
- UniSTS:215810

BI297266 (e-PCR)
- UniSTS:248118

BF386039 (e-PCR)
- UniSTS:243559

RH128094 (e-PCR)
- UniSTS:211402

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables histone H3R26 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R26 arginine deiminase activity	ISO Inferred from Sequence Orthology more info
enables histone arginine deiminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine deiminase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine deiminase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lymphocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lymphocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in euchromatin	IEA Inferred from Electronic Annotation more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein-arginine deiminase type-2

Names: peptidyl arginine deiminase, type 2; peptidyl arginine deiminase, type II; peptidylarginine deiminase II; protein-arginine deiminase type II

NP_058922.2

EC 3.5.3.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017226.2 → NP_058922.2 protein-arginine deiminase type-2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P20717

UniProtKB/TrEMBL

A6ITP8

Related

ENSRNOP00000010183.6, ENSRNOT00000010183.7

Conserved Domains (3) summary

pfam03068
Location:287 → 662

PAD; Protein-arginine deiminase (PAD)

pfam08526
Location:1 → 114

PAD_N; Protein-arginine deiminase (PAD) N-terminal domain

pfam08527
Location:116 → 274

PAD_M; Protein-arginine deiminase (PAD) middle domain