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Sh3d19 SH3 domain containing 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295171, updated on 2-Nov-2024

Summary

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Symbol
Sh3d19provided by RGD
Full Name
SH3 domain containing 19provided by RGD
Primary source
RGD:1304885
See related
EnsemblRapid:ENSRNOG00000011752 AllianceGenome:RGD:1304885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304885
Summary
Predicted to enable proline-rich region binding activity. Predicted to be involved in cytoskeleton organization; positive regulation of membrane protein ectodomain proteolysis; and regulation of cell morphogenesis. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Orthologous to human SH3D19 (SH3 domain containing 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 155.2), Adrenal (RPKM 124.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3d19 in Genome Data Viewer
Location:
2q34
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (173654234..173814030)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (171356244..171516042)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (185268028..185431834)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L7a-like Neighboring gene cleavage and polyadenylation specific factor 3, pseudogene 1 Neighboring gene serine protease 48 Neighboring gene small nucleolar RNA, C/D box 73A Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene ribosomal protein S3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. Tanaka M, et al. J Biol Chem, 2004 Oct 1. PMID 15280379
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-containing protein 19
Names
SH3 domain protein D19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433033.1 → NP_001419962.1  SH3 domain-containing protein 19 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6A086

  2. NM_001433034.1 → NP_001419963.1  SH3 domain-containing protein 19 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZMF0

RNA

  1. NR_197325.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  2. NR_197326.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    173654234..173814030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232783.4 → XP_006232845.1  SH3 domain-containing protein 19 isoform X4

    See identical proteins and their annotated locations for XP_006232845.1

    UniProtKB/TrEMBL
    A0A8I6AB73
    Related
    ENSRNOP00000083936.2, ENSRNOT00000097494.2
    Conserved Domains (3) summary
    cd11816
    Location:850 → 900
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:1015 → 1064
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:774 → 825
    SH3; Src Homology 3 domain superfamily

  2. XM_215597.11 → XP_215597.6  SH3 domain-containing protein 19 isoform X1

    Related
    ENSRNOP00000076208.3, ENSRNOT00000093640.3
    Conserved Domains (3) summary
    cd11816
    Location:850 → 900
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:1009 → 1058
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:774 → 825
    SH3; Src Homology 3 domain superfamily

  3. XM_006232785.5 → XP_006232847.1  SH3 domain-containing protein 19 isoform X5

    See identical proteins and their annotated locations for XP_006232847.1

    UniProtKB/TrEMBL
    A0A8I6AB73
    Conserved Domains (3) summary
    cd11816
    Location:780 → 830
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:945 → 994
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    cl17036
    Location:704 → 755
    SH3; Src Homology 3 domain superfamily

  4. XM_063282714.1 → XP_063138784.1  SH3 domain-containing protein 19 isoform X6

    Related
    ENSRNOP00000089094.2, ENSRNOT00000112954.2

  5. XM_039103745.2 → XP_038959673.1  SH3 domain-containing protein 19 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AB73
    Related
    ENSRNOP00000079295.2, ENSRNOT00000095856.2
    Conserved Domains (4) summary
    cd11816
    Location:791 → 841
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:956 → 1005
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:248 → 625
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:715 → 766
    SH3; Src Homology 3 domain superfamily

  6. XM_063282715.1 → XP_063138785.1  SH3 domain-containing protein 19 isoform X7

    Related
    ENSRNOP00000015803.5, ENSRNOT00000015802.8

  7. XM_039103746.2 → XP_038959674.1  SH3 domain-containing protein 19 isoform X3

    Related
    ENSRNOP00000095234.2, ENSRNOT00000106873.2
    Conserved Domains (4) summary
    cd11816
    Location:791 → 841
    SH3_Eve1_3; Third Src homology 3 domain of ADAM-binding protein Eve-1
    cd11818
    Location:950 → 999
    SH3_Eve1_5; Fifth Src homology 3 domain of ADAM-binding protein Eve-1
    PHA03247
    Location:248 → 625
    PHA03247; large tegument protein UL36; Provisional
    cl17036
    Location:715 → 766
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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