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Dap3 death associated protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295238, updated on 11-Apr-2024

Summary

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Official Symbol
Dap3provided by RGD
Official Full Name
death associated protein 3provided by RGD
Primary source
RGD:1305339
See related
Ensembl:ENSRNOG00000020373 AllianceGenome:RGD:1305339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within apoptotic mitochondrial changes. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be part of mitochondrial small ribosomal subunit. Orthologous to human DAP3 (death associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 101.3), Thymus (RPKM 95.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dap3 in Genome Data Viewer
Location:
2q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176617151..176645293, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174319341..174347489, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188225607..188255324, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 11 Neighboring gene gon-4 like Neighboring gene misato mitochondrial distribution and morphology regulator 1 Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene RUN and SH3 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis. Kim HR, et al. FASEB J, 2007 Jan. PMID 17135360
  2. The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins. Berger T, et al. J Cell Sci, 2000 Oct. PMID 11017876
  3. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. Harada T, et al. Apoptosis, 2010 Oct. PMID 20563667
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional characterization of a similar protein in mouse.
    Title: Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS29
Names
28S ribosomal protein S29, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011950.2 → NP_001011950.2  small ribosomal subunit protein mS29

    See identical proteins and their annotated locations for NP_001011950.2

    Status: VALIDATED

    Source sequence(s)
    AA964664, BC085878
    UniProtKB/TrEMBL
    A6J6B2, F7EZZ0, Q5U2T0
    Related
    ENSRNOP00000027608.5, ENSRNOT00000027608.8
    Conserved Domains (1) summary
    pfam10236
    Location:97 → 392
    DAP3; Mitochondrial ribosomal death-associated protein 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176617151..176645293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281611.1 → XP_063137681.1  small ribosomal subunit protein mS29 isoform X3

    UniProtKB/TrEMBL
    A6J6B2, F7EZZ0

  2. XM_039102039.2 → XP_038957967.1  small ribosomal subunit protein mS29 isoform X7

    Conserved Domains (1) summary
    pfam10236
    Location:97 → 299
    DAP3; Mitochondrial ribosomal death-associated protein 3

  3. XM_006232610.5 → XP_006232672.1  small ribosomal subunit protein mS29 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZZU0, Q5U2T0
    Related
    ENSRNOP00000084514.1
    Conserved Domains (1) summary
    pfam10236
    Location:97 → 362
    DAP3; Mitochondrial ribosomal death-associated protein 3

  4. XM_039102038.2 → XP_038957966.1  small ribosomal subunit protein mS29 isoform X6

    Conserved Domains (1) summary
    pfam10236
    Location:97 → 279
    DAP3; Mitochondrial ribosomal death-associated protein 3

  5. XM_063281614.1 → XP_063137684.1  small ribosomal subunit protein mS29 isoform X9

  6. XM_063281612.1 → XP_063137682.1  small ribosomal subunit protein mS29 isoform X4

  7. XM_063281613.1 → XP_063137683.1  small ribosomal subunit protein mS29 isoform X8

  8. XM_063281610.1 → XP_063137680.1  small ribosomal subunit protein mS29 isoform X2

  9. XM_063281609.1 → XP_063137679.1  small ribosomal subunit protein mS29 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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