U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pla2g1b phospholipase A2 group IB [ Rattus norvegicus (Norway rat) ]

Gene ID: 29526, updated on 2-Nov-2024

Summary

Official Symbol
Pla2g1bprovided by RGD
Official Full Name
phospholipase A2 group IBprovided by RGD
Primary source
RGD:61949
See related
EnsemblRapid:ENSRNOG00000001153 AllianceGenome:RGD:61949
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium-dependent phospholipase A2 activity and signaling receptor binding activity. Involved in fatty acid biosynthetic process; phospholipid metabolic process; and positive regulation of cell population proliferation. Located in cell surface and secretory granule. Orthologous to human PLA2G1B (phospholipase A2 group IB). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 1452.5), Liver (RPKM 409.6) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pla2g1b in Genome Data Viewer
Location:
12q16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46802932..46814511, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41142193..41151967, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46879346..46890234, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene sirtuin 4 Neighboring gene musashi RNA-binding protein 1 Neighboring gene uncharacterized LOC134481302 Neighboring gene uncharacterized LOC102547958

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
 
enables bile acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in arachidonate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response in mucosa IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil mediated immunity ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylcholine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of podocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of podocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of podocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of D-glucose import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT acts_upstream_of regulation of interleukin-1 production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phospholipase A2
Names
group IB phospholipase A2
phosphatidylcholine 2-acylhydrolase 1B
phospholipase A2, group 1B
phospholipase A2, group IB, pancreas
NP_113773.1
XP_008767444.1
XP_063127301.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031585.2NP_113773.1  phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_113773.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    P04055
    UniProtKB/TrEMBL
    A6J1T9, A6J1U0
    Conserved Domains (1) summary
    smart00085
    Location:24146
    PA2c; Phospholipase A2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    46802932..46814511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769222.4XP_008767444.1  phospholipase A2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2PYZ4, A6J1U0
    Related
    ENSRNOP00000001525.2, ENSRNOT00000001525.5
    Conserved Domains (1) summary
    smart00085
    Location:23145
    PA2c; Phospholipase A2
  2. XM_063271231.1XP_063127301.1  phospholipase A2 isoform X1

    UniProtKB/Swiss-Prot
    P04055
    UniProtKB/TrEMBL
    A6J1T9