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Pear1 platelet endothelial aggregation receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295293, updated on 2-Nov-2024

Summary

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Official Symbol
Pear1provided by RGD
Official Full Name
platelet endothelial aggregation receptor 1provided by RGD
Primary source
RGD:1305653
See related
EnsemblRapid:ENSRNOG00000014243 AllianceGenome:RGD:1305653
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305653
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction; platelet aggregation; and positive regulation of platelet activation. Predicted to act upstream of or within recognition of apoptotic cell. Predicted to be located in lamellipodium and phagocytic cup. Predicted to be active in plasma membrane. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 86.0), Kidney (RPKM 66.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pear1 in Genome Data Viewer
Location:
2q34
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175504184..175531969, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173206298..173234106, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187114219..187134209, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546356 Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene leucine rich repeat containing 71 Neighboring gene uncharacterized LOC134485635 Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor-related receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Absence of Pear1 does not affect murine platelet function in vivo. Criel M, et al. Thromb Res, 2016 Oct. PMID 27614188
  2. Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Wu HH, et al. Nat Neurosci, 2009 Dec. PMID 19915564, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188434

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within recognition of apoptotic cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
platelet endothelial aggregation receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134959.1 → NP_001128431.1  platelet endothelial aggregation receptor 1 precursor

    See identical proteins and their annotated locations for NP_001128431.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168665
    UniProtKB/TrEMBL
    A0A8I5Y1X3, B5DEG9
    Related
    ENSRNOP00000019502.5, ENSRNOT00000019502.9
    Conserved Domains (3) summary
    pfam00053
    Location:620 → 665
    Laminin_EGF; Laminin EGF domain
    pfam07546
    Location:25 → 93
    EMI; EMI domain
    cl21504
    Location:535 → 580
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175504184..175531969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281628.1 → XP_063137698.1  platelet endothelial aggregation receptor 1 isoform X1

  2. XM_039102054.2 → XP_038957982.1  platelet endothelial aggregation receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1X3, E9PTZ1
    Conserved Domains (3) summary
    pfam00053
    Location:620 → 665
    Laminin_EGF; Laminin EGF domain
    pfam07546
    Location:25 → 93
    EMI; EMI domain
    cl21504
    Location:535 → 580
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. XM_039102056.2 → XP_038957984.1  platelet endothelial aggregation receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1X3, E9PTZ1
    Conserved Domains (3) summary
    pfam00053
    Location:620 → 665
    Laminin_EGF; Laminin EGF domain
    pfam07546
    Location:25 → 93
    EMI; EMI domain
    cl21504
    Location:535 → 580
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  4. XM_063281627.1 → XP_063137697.1  platelet endothelial aggregation receptor 1 isoform X1

  5. XM_063281629.1 → XP_063137699.1  platelet endothelial aggregation receptor 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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