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Amhr2 anti-Mullerian hormone receptor type 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29530, updated on 2-Nov-2024

Summary

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Official Symbol
Amhr2provided by RGD
Official Full Name
anti-Mullerian hormone receptor type 2provided by RGD
Primary source
RGD:70964
See related
EnsemblRapid:ENSRNOG00000014850 AllianceGenome:RGD:70964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C14; MRII; MISRII
Summary
Enables transforming growth factor beta receptor activity, type II. Involved in female gonad development and male gonad development. Acts upstream of or within transforming growth factor beta receptor signaling pathway. Located in plasma membrane. Human ortholog(s) of this gene implicated in persistent Mullerian duct syndrome. Orthologous to human AMHR2 (anti-Mullerian hormone receptor type 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 106.1), Heart (RPKM 38.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amhr2 in Genome Data Viewer
Location:
7q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135454517..135470183)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133579152..133588874)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144052202..144060678)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Sp7 transcription factor Neighboring gene Sp1 transcription factor Neighboring gene uncharacterized LOC134479584 Neighboring gene proline rich 13 Neighboring gene poly(rC) binding protein 2 Neighboring gene mitogen activated protein kinase kinase kinase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity. Mendis-Handagama SM, et al. Histol Histopathol, 2006 Feb. PMID 16329036
  2. Transcriptional regulation of the rat Müllerian inhibiting substance type II receptor in rodent Leydig cells. Teixeira J, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570158, Free PMC Article
  3. Developmental expression of a candidate müllerian inhibiting substance type II receptor. Teixeira J, et al. Endocrinology, 1996 Jan. PMID 8536608
  4. A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct. Baarends WM, et al. Development, 1994 Jan. PMID 8119126
  5. The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors. Imhoff FM, et al. FEBS Lett, 2013 Jun 19. PMID 23624077

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. physiological function(s) of type 2 anti-Mullerian hormone receptor
    Title: The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors.
  2. Data suggest that Mullerian inhibiting substance (MIS) initiates an epithelial-to-mesenchymal transition of MISRI receptor-expressing cells and specifies the components of the receptor/SMAD8 signaling pathway by regulating their expression.
    Title: Müllerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Müllerian duct regression.
  3. examined the presence of AMH receptor type II (AMHR-II) in fetal Leydig cells (FLC) and cells in the adult Leydig cells lineage in the postnatal testis; presence of AMHR-II in postnatal FLC suggests a possible role by AMH on FLC
    Title: Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables anti-Mullerian hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables anti-Mullerian hormone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transforming growth factor beta receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity, type II IDA
Inferred from Direct Assay
more info
 PubMed 
enables transforming growth factor beta receptor activity, type II ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anti-Mullerian hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in anti-Mullerian hormone receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in blood vessel development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female gonad development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sex differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in sex differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anti-Muellerian hormone type-2 receptor
Names
AMH type II receptor
MIS type II receptor
anti-Muellerian hormone type II receptor
anti-Mullerian hormone receptor type 11 SV1
anti-Mullerian hormone receptor, type II
anti-Mullerian hormone type 2 receptor
NP_112260.1
XP_038934520.1
XP_038934521.1
XP_038934523.1
XP_038934524.1
XP_063119188.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030998.2 → NP_112260.1  anti-Muellerian hormone type-2 receptor precursor

    See identical proteins and their annotated locations for NP_112260.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q62893, Q63045, Q9R0A7
    UniProtKB/TrEMBL
    A6KCV2
    Related
    ENSRNOP00000020103.5, ENSRNOT00000020103.7
    Conserved Domains (2) summary
    pfam01064
    Location:61 → 119
    Activin_recp; Activin types I and II receptor domain
    cl21453
    Location:205 → 506
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135454517..135470183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078593.2 → XP_038934521.1  anti-Muellerian hormone type-2 receptor isoform X1

    UniProtKB/Swiss-Prot
    Q62893, Q63045, Q9R0A7
    UniProtKB/TrEMBL
    A6KCV2
    Conserved Domains (2) summary
    pfam01064
    Location:61 → 119
    Activin_recp; Activin types I and II receptor domain
    cl21453
    Location:205 → 506
    PKc_like; Protein Kinases, catalytic domain

  2. XM_063263118.1 → XP_063119188.1  anti-Muellerian hormone type-2 receptor isoform X2

  3. XM_039078592.2 → XP_038934520.1  anti-Muellerian hormone type-2 receptor isoform X1

    UniProtKB/Swiss-Prot
    Q62893, Q63045, Q9R0A7
    UniProtKB/TrEMBL
    A6KCV2
    Conserved Domains (2) summary
    pfam01064
    Location:61 → 119
    Activin_recp; Activin types I and II receptor domain
    cl21453
    Location:205 → 506
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039078596.2 → XP_038934524.1  anti-Muellerian hormone type-2 receptor isoform X3

    UniProtKB/TrEMBL
    A0A088DKH8, A6KCV3
    Related
    ENSRNOP00000069243.1, ENSRNOT00000091378.3
    Conserved Domains (2) summary
    pfam01064
    Location:61 → 119
    Activin_recp; Activin types I and II receptor domain
    cl21453
    Location:205 → 428
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039078595.2 → XP_038934523.1  anti-Muellerian hormone type-2 receptor isoform X2

    Conserved Domains (2) summary
    pfam01064
    Location:61 → 119
    Activin_recp; Activin types I and II receptor domain
    cl21453
    Location:206 → 429
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62893.1 GenPept UniProtKB/Swiss-Prot:Q62893

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