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Acp6 acid phosphatase 6, lysophosphatidic [ Rattus norvegicus (Norway rat) ]

Gene ID: 295305, updated on 2-Nov-2024

Summary

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Official Symbol
Acp6provided by RGD
Official Full Name
acid phosphatase 6, lysophosphatidicprovided by RGD
Primary source
RGD:1306336
See related
EnsemblRapid:ENSRNOG00000017494 AllianceGenome:RGD:1306336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable lysophosphatidic acid phosphatase activity. Predicted to be involved in lysobisphosphatidic acid metabolic process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human ACP6 (acid phosphatase 6, lysophosphatidic). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 97.0), Thymus (RPKM 80.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acp6 in Genome Data Viewer
Location:
2q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187400786..187421877)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184711975..184733067)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199284177..199305793)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553665 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1, pseudogene 2 Neighboring gene proline-rich protein 2-like Neighboring gene BCL9, transcription coactivator Neighboring gene uncharacterized LOC102549654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. Li J, et al. Protein Cell, 2013 Jul. PMID 23807634, Free PMC Article
  2. Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis. Hiroyama M, et al. J Biol Chem, 1999 Oct 8. PMID 10506173
  3. Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum. Takayama I, et al. Gut, 2002 Jun. PMID 12010880, Free PMC Article
  4. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116276

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lysophosphatidic acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophosphatidic acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lysobisphosphatidic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysobisphosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysophosphatidic acid phosphatase type 6
NP_001026815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031645.1 → NP_001026815.1  lysophosphatidic acid phosphatase type 6

    See identical proteins and their annotated locations for NP_001026815.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099131
    UniProtKB/TrEMBL
    F6Q1U6, Q4FZU0
    Related
    ENSRNOP00000104636.1, ENSRNOT00000135414.1
    Conserved Domains (1) summary
    cd07061
    Location:37 → 366
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    187400786..187421877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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