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Ntng1 netrin G1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295382, updated on 2-Nov-2024

Summary

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Official Symbol
Ntng1provided by RGD
Official Full Name
netrin G1provided by RGD
Primary source
RGD:1563465
See related
EnsemblRapid:ENSRNOG00000031136 AllianceGenome:RGD:1563465
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563465
Summary
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in several processes, including regulation of cell projection organization; regulation of neuron migration; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human NTNG1 (netrin G1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 56.6), Uterus (RPKM 30.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ntng1 in Genome Data Viewer
Location:
2q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (200151979..200515031, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (197462785..197827681, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (212695464..213073046, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene vav guanine nucleotide exchange factor 3 Neighboring gene uncharacterized LOC120100919 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120100921 Neighboring gene uncharacterized LOC102547648 Neighboring gene protein arginine methyltransferase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. Song YS, et al. J Cell Sci, 2013 Nov 1. PMID 23986473
  2. Complementary expression and neurite outgrowth activity of netrin-G subfamily members. Nakashiba T, et al. Mech Dev, 2002 Feb. PMID 11804778
  3. Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. Nakashiba T, et al. J Neurosci, 2000 Sep 1. PMID 10964959, Free PMC Article
  4. Netrin-G/NGL complexes encode functional synaptic diversification. Matsukawa H, et al. J Neurosci, 2014 Nov 19. PMID 25411505, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
netrin-G1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106465.1 → NP_001099935.1  netrin-G1 precursor

    See identical proteins and their annotated locations for NP_001099935.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473952
    UniProtKB/TrEMBL
    A0A8I5ZNR9, A6HV45, F1LWK9
    Related
    ENSRNOP00000060409.4, ENSRNOT00000066218.4
    Conserved Domains (3) summary
    smart00180
    Location:420 → 467
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    200151979..200515031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590780.3 → XP_017446269.1  netrin-G1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GA33, A0A8I6GIB6, A6HV43
    Related
    ENSRNOP00000079843.2, ENSRNOT00000114999.2
    Conserved Domains (3) summary
    cd00054
    Location:373 → 397
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  2. XM_008761394.4 → XP_008759616.2  netrin-G1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ARQ4, A0A8I6GIB6, A6HV46
    Related
    ENSRNOP00000095580.1, ENSRNOT00000110142.2
    Conserved Domains (3) summary
    cd00054
    Location:395 → 419
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)

  3. XM_017590776.3 → XP_017446265.1  netrin-G1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARZ4, A6HV44
    Related
    ENSRNOP00000089707.2, ENSRNOT00000100896.2

  4. XM_017590779.3 → XP_017446268.1  netrin-G1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBS1, A0A8I6GIB6, A6HV47
    Related
    ENSRNOP00000076604.1, ENSRNOT00000117900.2
    Conserved Domains (3) summary
    cd00054
    Location:415 → 439
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:296 → 342
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00055
    Location:71 → 295
    Laminin_N; Laminin N-terminal (Domain VI)
Nucleotide Protein Strain
Heading Accession and Version

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