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Dph5 diphthamide biosynthesis 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295394, updated on 14-Nov-2024

Summary

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Official Symbol
Dph5provided by RGD
Official Full Name
diphthamide biosynthesis 5provided by RGD
Primary source
RGD:1307867
See related
EnsemblRapid:ENSRNOG00000013719 AllianceGenome:RGD:1307867
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CGI-30; RGD1307867
Summary
Predicted to enable diphthine methyl ester synthase activity. Predicted to be involved in methylation and protein histidyl modification to diphthamide. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties. Orthologous to human DPH5 (diphthamide biosynthesis 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 66.0), Liver (RPKM 51.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dph5 in Genome Data Viewer
Location:
2q42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206489556..206540590)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (203804620..203858196)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (218834034..218866763)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548358 Neighboring gene uncharacterized LOC120100612 Neighboring gene solute carrier family 30 member 7 Neighboring gene uncharacterized LOC120100923 Neighboring gene exostosin-like glycosyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109155

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables diphthine methyl ester synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
diphthine methyl ester synthase
Names
DPH5 homolog
diphthine synthase
NP_001017449.1
XP_006233276.1
XP_038958011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017449.1 → NP_001017449.1  diphthine methyl ester synthase

    See identical proteins and their annotated locations for NP_001017449.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092598
    UniProtKB/TrEMBL
    A0A8I5ZL86, F7F6W5, Q569A7
    Related
    ENSRNOP00000018367.5, ENSRNOT00000018367.7
    Conserved Domains (1) summary
    PTZ00175
    Location:1 → 272
    PTZ00175; diphthine synthase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    206489556..206540590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233214.3 → XP_006233276.1  diphthine methyl ester synthase isoform X1

    See identical proteins and their annotated locations for XP_006233276.1

    UniProtKB/TrEMBL
    A0A8I5ZL86, F7F6W5, Q569A7
    Conserved Domains (1) summary
    PTZ00175
    Location:1 → 272
    PTZ00175; diphthine synthase; Provisional

  2. XM_039102083.2 → XP_038958011.1  diphthine methyl ester synthase isoform X2

    UniProtKB/TrEMBL
    A6HV83
    Conserved Domains (1) summary
    cl00304
    Location:1 → 176
    TP_methylase; S-AdoMet-dependent tetrapyrrole methylases
Nucleotide Protein Strain
Heading Accession and Version

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