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Bdh2 3-hydroxybutyrate dehydrogenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295458, updated on 2-Nov-2024

Summary

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Official Symbol
Bdh2provided by RGD
Official Full Name
3-hydroxybutyrate dehydrogenase 2provided by RGD
Primary source
RGD:1309898
See related
EnsemblRapid:ENSRNOG00000014490 AllianceGenome:RGD:1309898
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dhrs6
Summary
Predicted to enable 3-hydroxybutyrate dehydrogenase activity; NAD binding activity; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including fatty acid beta-oxidation; heme metabolic process; and siderophore biosynthetic process. Predicted to act upstream of with a positive effect on intracellular sequestering of iron ion. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 285.2), Heart (RPKM 53.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bdh2 in Genome Data Viewer
Location:
2q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (226376346..226397010)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223702410..223723076)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240461505..240482149)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 12A, pseudogene 1 Neighboring gene centromere protein E Neighboring gene solute carrier family 9 member B2 Neighboring gene solute carrier family 9 member B1 Neighboring gene uncharacterized LOC134485973

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. Guo K, et al. J Biol Chem, 2006 Apr 14. PMID 16380372
  2. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Devireddy LR, et al. Cell, 2010 Jun 11. PMID 20550936, Free PMC Article
  3. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-hydroxybutyrate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxybutyrate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-hydroxybutyrate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables 4-oxoproline reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in heme metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_positive_effect intracellular sequestering of iron ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect intracellular sequestering of iron ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in siderophore biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siderophore biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in siderophore biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 6
Names
(R)-beta-hydroxybutyrate dehydrogenase
3-hydroxybutyrate dehydrogenase, type 2
4-oxo-L-proline reductase
R-beta-hydroxybutyrate dehydrogenase
dehydrogenase/reductase (SDR family) member 6
oxidoreductase UCPA
short chain dehydrogenase/reductase family 15C member 1
NP_001099943.1
XP_006233384.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106473.1 → NP_001099943.1  dehydrogenase/reductase SDR family member 6

    See identical proteins and their annotated locations for NP_001099943.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473952
    UniProtKB/TrEMBL
    A0A0A0MXX5
    Related
    ENSRNOP00000019507.4, ENSRNOT00000019507.7
    Conserved Domains (2) summary
    cd05368
    Location:15 → 255
    DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
    PRK06138
    Location:12 → 254
    PRK06138; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    226376346..226397010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233322.5 → XP_006233384.1  dehydrogenase/reductase SDR family member 6 isoform X1

    See identical proteins and their annotated locations for XP_006233384.1

    UniProtKB/Swiss-Prot
    D4A1J4
    UniProtKB/TrEMBL
    A6HVW3
    Conserved Domains (2) summary
    cd05368
    Location:5 → 245
    DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
    PRK06138
    Location:2 → 244
    PRK06138; short chain dehydrogenase; Provisional

RNA

  1. XR_010063596.1 RNA Sequence

    Related
    ENSRNOT00000095079.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A1J4.2 GenPept UniProtKB/Swiss-Prot:D4A1J4

Gene LinkOut

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