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MSH6 mutS homolog 6 [ Homo sapiens (human) ]

Gene ID: 2956, updated on 2-Nov-2024

Summary

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Official Symbol
MSH6provided by HGNC
Official Full Name
mutS homolog 6provided by HGNC
Primary source
HGNC:HGNC:7329
See related
Ensembl:ENSG00000116062 MIM:600678; AllianceGenome:HGNC:7329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTBP; HSAP; p160; GTMBP; MSH-6; HNPCC5; LYNCH5; MMRCS3
Summary
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in ovary (RPKM 15.4), testis (RPKM 14.1) and 25 other tissues See more
Orthologs
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Genomic context

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See MSH6 in Genome Data Viewer
Location:
2p16.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (47783145..47810101)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (47789083..47816050)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (48010284..48037240)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RBIS pseudogene 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:47975285-47975438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15740 Neighboring gene uncharacterized LOC105374589 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48008525-48008706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11469 Neighboring gene ribosomal protein L36a pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15743 Neighboring gene F-box protein 11 Neighboring gene Sharpr-MPRA regulatory region 9679 Neighboring gene RPS27A pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:48129098-48129367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:48131440-48132226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11471 Neighboring gene uncharacterized LOC100506235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11473 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:48133799-48134583

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Quantitative evaluation of MSI testing using NGS detects the imperceptible microsatellite changed caused by MSH6 deficiency. Yamamoto G, et al. Fam Cancer, 2021 Apr. PMID 32949329
  2. MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry. Okkels H, et al. Appl Immunohistochem Mol Morphol, 2012 Oct. PMID 22495361
  3. Thirty-nine-year-old with familial colon cancer, and variant of undetermined significance in MSH6. Adonizio C, et al. Semin Oncol, 2012 Apr. PMID 22484182
  4. Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome. Drost M, et al. Genet Med, 2020 May. PMID 31965077, Free PMC Article
  5. Next-generation sequencing in thymic epithelial tumors uncovered novel genomic aberration sites and strong correlation between TMB and MSH6 single nucleotide variations. Chen K, et al. Cancer Lett, 2020 Apr 28. PMID 32061754

See all (525) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of MSH6 augments the antineoplastic efficacy of cisplatin in non-small cell lung cancer as autophagy modulator.
    Title: Inhibition of MSH6 augments the antineoplastic efficacy of cisplatin in non-small cell lung cancer as autophagy modulator.
  2. Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study.
    Title: Assessing the role of MSH2 and MSH6 gene expression deficiency in prostate cancer progression, a cross-sectional study.
  3. Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation.
    Title: Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation.
  4. Attenuated adenomatous polyposis with MSH6 variation: Two case reports.
    Title: Attenuated adenomatous polyposis with MSH6 variation: Two case reports.
  5. TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner.
    Title: TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner.
  6. Mismatch repair gene MSH6 correlates with the prognosis, immune status and immune checkpoint inhibitors response of endometrial cancer.
    Title: Mismatch repair gene MSH6 correlates with the prognosis, immune status and immune checkpoint inhibitors response of endometrial cancer.
  7. Discordant Staining Patterns and Microsatellite Results in Tumors of MSH6 Pathogenic Variant Carriers.
    Title: Discordant Staining Patterns and Microsatellite Results in Tumors of MSH6 Pathogenic Variant Carriers.
  8. Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome-Associated Colorectal Carcinomas.
    Title: Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome-Associated Colorectal Carcinomas.
  9. Structural, functional analysis and association of MSH6 rs1800932, rs1042821 polymorphisms with clinical outcome in North Indian lung cancer patients treated with platinum-based doublet chemotherapy.
    Title: Structural, functional analysis and association of MSH6 rs1800932, rs1042821 polymorphisms with clinical outcome in North Indian lung cancer patients treated with platinum-based doublet chemotherapy.
  10. Novel MSH6 mutation predicted metastasis in eyelid and periocular squamous cell carcinoma.
    Title: Novel MSH6 mutation predicted metastasis in eyelid and periocular squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (238)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MSH6 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Endometrial carcinoma
MedGen: C0476089 OMIM: 608089 GeneReviews: Not available
Compare labs
Lynch syndrome
MedGen: C4552100 GeneReviews: Lynch Syndrome
Compare labs
Lynch syndrome 5
MedGen: C1833477 OMIM: 614350 GeneReviews: Not available
Compare labs
Mismatch repair cancer syndrome 3
MedGen: C5436807 OMIM: 619097 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-10-13)

ClinGen Genome Curation PagePubMed
Triplosensitivity

No evidence available (Last evaluated 2021-10-13)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours in patients with COPD.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to MutLalpha complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to four-way junction DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mismatched DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to mismatched DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mismatched DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to oxidized purine DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single guanine insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single thymine insertion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in determination of adult lifespan ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in maintenance of DNA repeat elements IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mismatch repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to UV ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in somatic hypermutation of immunoglobulin genes ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in somatic recombination of immunoglobulin gene segments ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
part_of MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MutSalpha complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MutSalpha complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein Msh6
Names
G/T mismatch-binding protein
mutS protein homolog 6
mutS-alpha 160 kDa subunit
mutS-like protein 6
sperm-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007111.1 RefSeqGene

    Range
    4936..28807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_219

mRNA and Protein(s)

  1. NM_000179.3 → NP_000170.1  DNA mismatch repair protein Msh6 isoform 1

    See identical proteins and their annotated locations for NP_000170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    BC071594, U54777
    Consensus CDS
    CCDS1836.1
    UniProtKB/Swiss-Prot
    B4DF41, B4E3I4, F5H2F9, O43706, O43917, P52701, Q8TCX4, Q9BTB5
    UniProtKB/TrEMBL
    A0A8V8TQJ0
    Related
    ENSP00000234420.5, ENST00000234420.11
    Conserved Domains (7) summary
    cd05837
    Location:88 → 195
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    COG0249
    Location:407 → 1336
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:407 → 525
    MutS_I; MutS domain I
    pfam05188
    Location:538 → 692
    MutS_II; MutS domain II
    pfam05190
    Location:932 → 1024
    MutS_IV; MutS family domain IV
    pfam05192
    Location:739 → 827
    MutS_III; MutS domain III
    cl21455
    Location:1091 → 1313
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001281492.2 → NP_001268421.1  DNA mismatch repair protein Msh6 isoform 2

    See identical proteins and their annotated locations for NP_001268421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks two exons in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK293921, BC071594
    Consensus CDS
    CCDS62906.1
    UniProtKB/TrEMBL
    A0A8V8TQJ0
    Related
    ENSP00000446475.1, ENST00000540021.6
    Conserved Domains (6) summary
    COG0249
    Location:277 → 1206
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:277 → 395
    MutS_I; MutS domain I
    pfam05188
    Location:408 → 562
    MutS_II; MutS domain II
    pfam05190
    Location:802 → 894
    MutS_IV; MutS family domain IV
    pfam05192
    Location:609 → 697
    MutS_III; MutS domain III
    cl21455
    Location:961 → 1183
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001281493.2 → NP_001268422.1  DNA mismatch repair protein Msh6 isoform 3

    See identical proteins and their annotated locations for NP_001268422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AC006509, BC071594
    Conserved Domains (6) summary
    COG0249
    Location:105 → 1034
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:105 → 223
    MutS_I; MutS domain I
    pfam05188
    Location:236 → 390
    MutS_II; MutS domain II
    pfam05190
    Location:630 → 722
    MutS_IV; MutS family domain IV
    pfam05192
    Location:437 → 525
    MutS_III; MutS domain III
    cl21455
    Location:789 → 1011
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001281494.2 → NP_001268423.1  DNA mismatch repair protein Msh6 isoform 3

    See identical proteins and their annotated locations for NP_001268423.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a dowstream start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AC006509, AK304735, BC071594
    Conserved Domains (6) summary
    COG0249
    Location:105 → 1034
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:105 → 223
    MutS_I; MutS domain I
    pfam05188
    Location:236 → 390
    MutS_II; MutS domain II
    pfam05190
    Location:630 → 722
    MutS_IV; MutS family domain IV
    pfam05192
    Location:437 → 525
    MutS_III; MutS domain III
    cl21455
    Location:789 → 1011
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001406795.1 → NP_001393724.1  DNA mismatch repair protein Msh6 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006509

  6. NM_001406796.1 → NP_001393725.1  DNA mismatch repair protein Msh6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/Swiss-Prot
    B4DF41, B4E3I4, F5H2F9, O43706, O43917, P52701, Q8TCX4, Q9BTB5

  7. NM_001406797.1 → NP_001393726.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55
    Related
    ENSP00000501310.1, ENST00000673637.1

  8. NM_001406798.1 → NP_001393727.1  DNA mismatch repair protein Msh6 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC006509
    Related
    ENSP00000514752.2, ENST00000700004.2

  9. NM_001406799.1 → NP_001393728.1  DNA mismatch repair protein Msh6 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC006509

  10. NM_001406800.1 → NP_001393729.1  DNA mismatch repair protein Msh6 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC006509

  11. NM_001406801.1 → NP_001393730.1  DNA mismatch repair protein Msh6 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC006509

  12. NM_001406802.1 → NP_001393731.1  DNA mismatch repair protein Msh6 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC006509

  13. NM_001406803.1 → NP_001393732.1  DNA mismatch repair protein Msh6 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC006509

  14. NM_001406804.1 → NP_001393733.1  DNA mismatch repair protein Msh6 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC006509

  15. NM_001406805.1 → NP_001393734.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55

  16. NM_001406806.1 → NP_001393735.1  DNA mismatch repair protein Msh6 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC006509

  17. NM_001406807.1 → NP_001393736.1  DNA mismatch repair protein Msh6 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC006509

  18. NM_001406808.1 → NP_001393737.1  DNA mismatch repair protein Msh6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC006509

  19. NM_001406809.1 → NP_001393738.1  DNA mismatch repair protein Msh6 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/Swiss-Prot
    B4DF41, B4E3I4, F5H2F9, O43706, O43917, P52701, Q8TCX4, Q9BTB5

  20. NM_001406811.1 → NP_001393740.1  DNA mismatch repair protein Msh6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006509

  21. NM_001406812.1 → NP_001393741.1  DNA mismatch repair protein Msh6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006509

  22. NM_001406813.1 → NP_001393742.1  DNA mismatch repair protein Msh6 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006509

  23. NM_001406814.1 → NP_001393743.1  DNA mismatch repair protein Msh6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006509

  24. NM_001406815.1 → NP_001393744.1  DNA mismatch repair protein Msh6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006509

  25. NM_001406816.1 → NP_001393745.1  DNA mismatch repair protein Msh6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006509

  26. NM_001406817.1 → NP_001393746.1  DNA mismatch repair protein Msh6 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A8V8TPJ4
    Related
    ENSP00000514749.1, ENST00000700000.1

  27. NM_001406818.1 → NP_001393747.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55
    Related
    ENSP00000397484.2, ENST00000455383.6

  28. NM_001406819.1 → NP_001393748.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55
    Related
    ENSP00000390382.2, ENST00000420813.6

  29. NM_001406820.1 → NP_001393749.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55
    Related
    ENSP00000406248.2, ENST00000411819.2

  30. NM_001406821.1 → NP_001393750.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55

  31. NM_001406822.1 → NP_001393751.1  DNA mismatch repair protein Msh6 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC006509

  32. NM_001406823.1 → NP_001393752.1  DNA mismatch repair protein Msh6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006509

  33. NM_001406824.1 → NP_001393753.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55

  34. NM_001406825.1 → NP_001393754.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55

  35. NM_001406826.1 → NP_001393755.1  DNA mismatch repair protein Msh6 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC006509

  36. NM_001406827.1 → NP_001393756.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55

  37. NM_001406828.1 → NP_001393757.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55

  38. NM_001406829.1 → NP_001393758.1  DNA mismatch repair protein Msh6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006509

  39. NM_001406830.1 → NP_001393759.1  DNA mismatch repair protein Msh6 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC006509
    UniProtKB/TrEMBL
    A0A494C0M1, C9J7Y7, C9J8Y8, C9JH55

  40. NM_001406831.1 → NP_001393760.1  DNA mismatch repair protein Msh6 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC006509

  41. NM_001406832.1 → NP_001393761.1  DNA mismatch repair protein Msh6 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC006509
    Related
    ENST00000700005.1

  42. NM_001407362.1 → NP_001394291.1  DNA mismatch repair protein Msh6 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC006509

RNA

  1. NR_176256.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006509

  2. NR_176257.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006509

  3. NR_176258.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006509
    Related
    ENST00000445503.5

  4. NR_176259.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006509

  5. NR_176261.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006509
    Related
    ENST00000699999.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    47783145..47810101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    47789083..47816050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52701.2 GenPept UniProtKB/Swiss-Prot:P52701

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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