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Crabp2 cellular retinoic acid binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29563, updated on 2-Nov-2024

Summary

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Symbol
Crabp2provided by RGD
Full Name
cellular retinoic acid binding protein 2provided by RGD
Primary source
RGD:62070
See related
AllianceGenome:RGD:62070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables retinoic acid binding activity. Involved in retinoic acid biosynthetic process. Predicted to be located in endoplasmic reticulum and nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 95.9), Thymus (RPKM 65.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Crabp2 in Genome Data Viewer
Location:
2q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175714862..175719208)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173417004..173421352)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187322416..187326794)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene nestin Neighboring gene brevican

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cellular retinoic acid-binding protein II gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus. Li XH, et al. J Biol Chem, 2003 Sep 12. PMID 12842898
  2. Inducible expression of cellular retinoic acid-binding protein II in rat ovary: gonadotropin regulation during luteal development. Bucco RA, et al. Endocrinology, 1995 Jun. PMID 7750498
  3. A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. Sessler RJ, et al. Mol Cell, 2005 Apr 29. PMID 15866176
  4. Expression of the cellular retinoic acid binding proteins, type II and type I, in mature rat olfactory epithelium. Asson-Batres MA, et al. Cell Tissue Res, 2003 Apr. PMID 12684871
  5. Affinity purification of retinoic acid-binding proteins using immobilized 4-(2-hydroxyethoxy)retinoic acid. Chapman JM, et al. Protein Expr Purif, 1990 Sep. PMID 1967079

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both CRABP II and CRABP I proteins and the mRNAs that encode them are present in postnatal rat olfactory epithelium; CRABP type II immunoreactivity was not observed in the mature rat retina
    Title: Expression of the cellular retinoic acid binding proteins, type II and type I, in mature rat olfactory epithelium.
  2. Gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus.
    Title: Cellular retinoic acid-binding protein II gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding TAS
Traceable Author Statement
more info
 PubMed 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retinoic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables retinoic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables retinol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid biosynthetic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in retinoic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cellular retinoic acid-binding protein 2
Names
CRABP-II
cellular lipid-binding protein
cellular retinoic acid-binding protein 2-like
cellular retinoic acid-binding protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017244.2 → NP_058940.1  cellular retinoic acid-binding protein 2

    See identical proteins and their annotated locations for NP_058940.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P51673
    UniProtKB/TrEMBL
    A0A8L2Q848
    Conserved Domains (1) summary
    cl10502
    Location:3 → 139
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175714862..175719208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51673.2 GenPept UniProtKB/Swiss-Prot:P51673

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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