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Pla2r1 phospholipase A2 receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295631, updated on 31-Mar-2024

Summary

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Symbol
Pla2r1provided by RGD
Full Name
phospholipase A2 receptor 1provided by RGD
Primary source
RGD:1309777
See related
Ensembl:ENSRNOG00000008129 AllianceGenome:RGD:1309777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phospholipase binding activity and signaling receptor activity. Predicted to be involved in several processes, including negative regulation of phospholipase A2 activity; oxidative stress-induced premature senescence; and regulation of arachidonic acid secretion. Predicted to be located in cell surface and extracellular region. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human PLA2R1 (phospholipase A2 receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 24.8), Adrenal (RPKM 22.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pla2r1 in Genome Data Viewer
Location:
3q21
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (65292629..65422462, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44883943..45013793, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (46488963..46621873, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101907 Neighboring gene microRNA 6216 Neighboring gene lymphocyte antigen 75 Neighboring gene integrin subunit beta 6 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC108350379

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. Granata F, et al. J Immunol, 2005 Jan 1. PMID 15611272
  2. Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. Silliman CC, et al. Am J Physiol Cell Physiol, 2002 Oct. PMID 12225974
  3. The M-type receptor PLA2R regulates senescence through the p53 pathway. Augert A, et al. EMBO Rep, 2009 Mar. PMID 19197340, Free PMC Article
  4. sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor. Pan Y, et al. Sci Rep, 2014 Oct 22. PMID 25335547, Free PMC Article
  5. Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells. Fonteh AN, et al. J Immunol, 2000 Sep 1. PMID 10946309

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
    Title: Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in oxidative stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in oxidative stress-induced premature senescence ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of arachidonic acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of podocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in replicative senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in replicative senescence ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
secretory phospholipase A2 receptor
Names
secretory phospholipase A2 receptor-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100837.1 → NP_001094307.1  secretory phospholipase A2 receptor precursor

    See identical proteins and their annotated locations for NP_001094307.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473983
    UniProtKB/TrEMBL
    A6JF83, F1M495
    Related
    ENSRNOP00000011003.6, ENSRNOT00000011003.7
    Conserved Domains (4) summary
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:46 → 143
    RICIN; Ricin-type beta-trefoil
    cd00062
    Location:173 → 220
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00161
    Location:54 → 133
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    65292629..65422462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104479.2 → XP_038960407.1  secretory phospholipase A2 receptor isoform X1

    Conserved Domains (1) summary
    smart00034
    Location:146 → 270
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

  2. XM_039104480.2 → XP_038960408.1  secretory phospholipase A2 receptor isoform X2

    Conserved Domains (3) summary
    smart00034
    Location:378 → 502
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:46 → 143
    RICIN; Ricin-type beta-trefoil
    cd00062
    Location:173 → 220
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
Nucleotide Protein Strain
Heading Accession and Version

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