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Ube2l6 ubiquitin-conjugating enzyme E2L 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295704, updated on 2-Nov-2024

Summary

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Official Symbol
Ube2l6provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2L 6provided by RGD
Primary source
RGD:1307960
See related
EnsemblRapid:ENSRNOG00000030467 AllianceGenome:RGD:1307960
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ISG15 transferase activity; ubiquitin binding activity; and ubiquitin conjugating enzyme activity. Predicted to be involved in innate immune response; protein modification by small protein conjugation; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within modification-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human UBE2L6 (ubiquitin conjugating enzyme E2 L6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 83.5), Lung (RPKM 49.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2l6 in Genome Data Viewer
Location:
3q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90279705..90294721)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69873025..69888042)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72191533..72206190)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene serpin family G member 1 Neighboring gene smoothelin-like 1 Neighboring gene uncharacterized LOC120101592 Neighboring gene translocase of inner mitochondrial membrane 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Giannakopoulos NV, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16139798
  2. Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Kim KI, et al. Mol Cell Biol, 2004 Nov. PMID 15485925, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ISG15 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ISG15 transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
  
involved_in ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within modification-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin/ISG15-conjugating enzyme E2 L6
Names
E2 ubiquitin-conjugating enzyme L6
ubcM8
ubiquitin carrier protein L6
ubiquitin-protein ligase L6
NP_001019926.1
XP_017447037.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024755.1 → NP_001019926.1  ubiquitin/ISG15-conjugating enzyme E2 L6

    See identical proteins and their annotated locations for NP_001019926.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097364
    UniProtKB/Swiss-Prot
    Q4V8J2
    UniProtKB/TrEMBL
    A0A8L2QJE0, A6HMR6
    Related
    ENSRNOP00000095336.2, ENSRNOT00000106051.2
    Conserved Domains (2) summary
    COG5078
    Location:1 → 147
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:6 → 144
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90279705..90294721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591548.3 → XP_017447037.1  ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1

    Conserved Domains (1) summary
    pfam00179
    Location:5 → 108
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8J2.1 GenPept UniProtKB/Swiss-Prot:Q4V8J2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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