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Tnks1bp1 tankyrase 1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295707, updated on 10-Jul-2024

Summary

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Official Symbol
Tnks1bp1provided by RGD
Official Full Name
tankyrase 1 binding protein 1provided by RGD
Primary source
RGD:1312021
See related
EnsemblRapid:ENSRNOG00000009195 AllianceGenome:RGD:1312021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ankyrin repeat binding activity and enzyme binding activity. Predicted to be involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Predicted to be located in several cellular components, including actin cytoskeleton; adherens junction; and plasma membrane. Predicted to be part of CCR4-NOT complex. Predicted to be active in heterochromatin and nucleus. Orthologous to human TNKS1BP1 (tankyrase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 243.4), Adrenal (RPKM 105.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnks1bp1 in Genome Data Viewer
Location:
3q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90542006..90566720)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (70135335..70160071)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72458520..72483206)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene purinergic receptor P2X 3 Neighboring gene structure specific recognition protein 1 Neighboring gene apelin receptor Neighboring gene leucine rich repeat containing 55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). Seimiya H, et al. J Biol Chem, 2002 Apr 19. PMID 11854288
  2. TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1. Zou LH, et al. Oncotarget, 2015 Mar 30. PMID 25749521, Free PMC Article
  3. Human Ccr4-Not complexes contain variable deadenylase subunits. Lau NC, et al. Biochem J, 2009 Aug 27. PMID 19558367
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ankyrin repeat binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
182 kDa tankyrase-1-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429862.1 → NP_001416791.1  182 kDa tankyrase-1-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D3ZF26

  2. NM_001429863.1 → NP_001416792.1  182 kDa tankyrase-1-binding protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D3ZF26

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90542006..90566720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234486.5 → XP_006234548.1  182 kDa tankyrase-1-binding protein isoform X1

    Related
    ENSRNOP00000012209.4, ENSRNOT00000012209.9
    Conserved Domains (1) summary
    pfam15327
    Location:1533 → 1697
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  2. XM_017592170.3 → XP_017447659.1  182 kDa tankyrase-1-binding protein isoform X1

    UniProtKB/TrEMBL
    D3ZF26
    Conserved Domains (1) summary
    pfam15327
    Location:1533 → 1697
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  3. XM_006234485.5 → XP_006234547.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006234547.1

    UniProtKB/TrEMBL
    D3ZF26
    Conserved Domains (1) summary
    pfam15327
    Location:1533 → 1697
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  4. XM_006234484.5 → XP_006234546.1  182 kDa tankyrase-1-binding protein isoform X1

    Conserved Domains (1) summary
    pfam15327
    Location:1533 → 1697
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  5. XM_039106449.2 → XP_038962377.1  182 kDa tankyrase-1-binding protein isoform X2

    UniProtKB/TrEMBL
    A6HMT3
    Conserved Domains (1) summary
    pfam15327
    Location:928 → 1091
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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