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Bcat1 branched chain amino acid transaminase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29592, updated on 2-Nov-2024

Summary

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Official Symbol
Bcat1provided by RGD
Official Full Name
branched chain amino acid transaminase 1provided by RGD
Primary source
RGD:2195
See related
EnsemblRapid:ENSRNOG00000015514 AllianceGenome:RGD:2195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bcatc
Summary
Enables branched-chain-amino-acid transaminase activity and identical protein binding activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 1453.7) and Uterus (RPKM 95.1) See more
Orthologs
human mouse all
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Genomic context

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See Bcat1 in Genome Data Viewer
Location:
4q44
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (179695662..179777973, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (177964834..178046573, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (179259305..179340021, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554453 Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene electron transfer flavoprotein regulatory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids. García-Espinosa MA, et al. J Neurochem, 2007 Mar. PMID 17348860
  2. Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury. Kholodilov NG, et al. Brain Res Mol Brain Res, 2000 Feb 22. PMID 10686349
  3. Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture. Bixel MG, et al. J Histochem Cytochem, 1997 May. PMID 9154155
  4. Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic rats. Bradamante V, et al. Arzneimittelforschung, 2006. PMID 16572919
  5. Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme. Hutson SM, et al. J Biol Chem, 1995 Dec 22. PMID 8530459

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage.
    Title: BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage.
  2. this metabolic enzyme is expressed throughout the brain and spinal cord, with distinct differences in regional and intracellular patterns of expression.
    Title: Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105472

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-leucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-valine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables branched-chain-amino-acid transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables branched-chain-amino-acid transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables branched-chain-amino-acid transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables branched-chain-amino-acid transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables branched-chain-amino-acid transaminase activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within branched-chain amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
branched-chain-amino-acid aminotransferase, cytosolic
Names
BCAT(c)
branched chain amino acid transaminase 1, cytosolic
branched chain aminotransferase 1, cytosolic
NP_001380930.1
NP_058949.1
XP_008761592.1
XP_008761594.1
XP_008761595.1
XP_063141757.1
XP_063141758.1
XP_063141759.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394001.2 → NP_001380930.1  branched-chain-amino-acid aminotransferase, cytosolic isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K7K5, A6IMZ3, Q99JD5
    Related
    ENSRNOP00000074245.1, ENSRNOT00000080410.3
    Conserved Domains (1) summary
    PRK13357
    Location:52 → 391
    PRK13357; branched-chain amino acid aminotransferase; Provisional

  2. NM_017253.4 → NP_058949.1  branched-chain-amino-acid aminotransferase, cytosolic isoform 1

    See identical proteins and their annotated locations for NP_058949.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P54690
    UniProtKB/TrEMBL
    A6IMZ1, A6IMZ3
    Related
    ENSRNOP00000085607.1, ENSRNOT00000119115.2
    Conserved Domains (2) summary
    PRK13357
    Location:64 → 403
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:105 → 400
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    179695662..179777973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285688.1 → XP_063141758.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X3

    UniProtKB/TrEMBL
    A0A0G2K7K5, Q99JD5

  2. XM_008763372.3 → XP_008761594.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X3

    See identical proteins and their annotated locations for XP_008761594.1

    UniProtKB/TrEMBL
    A0A0G2K7K5, A6IMZ3, Q99JD5
    Conserved Domains (1) summary
    PRK13357
    Location:52 → 391
    PRK13357; branched-chain amino acid aminotransferase; Provisional

  3. XM_063285689.1 → XP_063141759.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X4

    UniProtKB/TrEMBL
    A0A0G2K7K5, Q99JD5
    Related
    ENSRNOP00000090195.1, ENSRNOT00000117044.2

  4. XM_063285687.1 → XP_063141757.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X1

  5. XM_008763370.4 → XP_008761592.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVC5, A6IMZ3
    Conserved Domains (2) summary
    PRK13357
    Location:81 → 420
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:122 → 417
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

  6. XM_008763373.3 → XP_008761595.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X5

    See identical proteins and their annotated locations for XP_008761595.1

    UniProtKB/TrEMBL
    A0A8L2QAQ9, A6IMZ4
    Related
    ENSRNOP00000021193.6, ENSRNOT00000021193.9
    Conserved Domains (2) summary
    PRK13357
    Location:51 → 390
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:92 → 387
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54690.1 GenPept UniProtKB/Swiss-Prot:P54690

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