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Apip APAF1 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 295961, updated on 18-Sep-2024

Summary

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Official Symbol
Apipprovided by RGD
Official Full Name
APAF1 interacting proteinprovided by RGD
Primary source
RGD:1564562
See related
EnsemblRapid:ENSRNOG00000007446 AllianceGenome:RGD:1564562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564562
Summary
Predicted to enable identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Predicted to be involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in cytoskeleton and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 40.0), Kidney (RPKM 28.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Apip in Genome Data Viewer
Location:
3q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (109886919..109913295)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (89431964..89458000)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (92969128..92998104)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101453 Neighboring gene uncharacterized LOC134486131 Neighboring gene pyruvate dehydrogenase complex, component X Neighboring gene RNA, U6 small nuclear 434 Neighboring gene ets homologous factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. Kang W, et al. Proc Natl Acad Sci U S A, 2014 Jan 7. PMID 24367089, Free PMC Article
  2. Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway. Mary C, et al. PLoS One, 2012. PMID 23285211, Free PMC Article
  3. Suppression of hypoxic cell death by APIP-induced sustained activation of AKT and ERK1/2. Cho DH, et al. Oncogene, 2007 Apr 26. PMID 17086211
  4. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Ko DC, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22837397, Free PMC Article
  5. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein. Cho DH, et al. J Biol Chem, 2004 Sep 17. PMID 15262985

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methylthioribulose 1-phosphate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylthioribulose 1-phosphate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from S-adenosylmethionine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methylthioribulose-1-phosphate dehydratase
Names
probable methylthioribulose-1-phosphate dehydratase
NP_001099962.2
XP_038960457.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106492.2 → NP_001099962.2  methylthioribulose-1-phosphate dehydratase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNQ5, D3ZUI1
    Related
    ENSRNOP00000009797.6, ENSRNOT00000009797.8
    Conserved Domains (1) summary
    TIGR03328
    Location:27 → 225
    salvage_mtnB; methylthioribulose-1-phosphate dehydratase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    109886919..109913295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104529.2 → XP_038960457.1  methylthioribulose-1-phosphate dehydratase isoform X1

    UniProtKB/TrEMBL
    A6HNQ6
    Conserved Domains (1) summary
    cl00214
    Location:1 → 154
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
Nucleotide Protein Strain
Heading Accession and Version

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