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Ino80 INO80 complex ATPase subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 296084, updated on 17-Aug-2024

Summary

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Official Symbol
Ino80provided by RGD
Official Full Name
INO80 complex ATPase subunitprovided by RGD
Primary source
RGD:1310969
See related
EnsemblRapid:ENSRNOG00000014483 AllianceGenome:RGD:1310969
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Inoc1; RGD1310969
Summary
Predicted to enable several functions, including ATP hydrolysis activity; alpha-tubulin binding activity; and histone binding activity. Predicted to be involved in several processes, including cellular response to radiation; chromosome organization; and regulation of cellular macromolecule biosynthetic process. Predicted to be located in cytosol and nuclear body. Predicted to be part of Ino80 complex. Orthologous to human INO80 (INO80 complex ATPase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 92.1), Spleen (RPKM 90.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ino80 in Genome Data Viewer
Location:
3q35
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126822280..126919532, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106368455..106465716, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111186371..111266542, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene delta like canonical Notch ligand 4 like 1 Neighboring gene delta like canonical Notch ligand 4 Neighboring gene ChaC glutathione-specific gamma-glutamylcyclotransferase 1 Neighboring gene developmental pluripotency-associated protein 3 Neighboring gene SH3 domain-binding protein 5-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. Hur SK, et al. Cell Mol Life Sci, 2010 Jul. PMID 20237820, Free PMC Article
  2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. Bakshi R, et al. Biochem Biophys Res Commun, 2006 Jan 6. PMID 16298340
  3. Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes. Park EJ, et al. Biochem J, 2010 Oct 15. PMID 20687897
  4. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Jiang Y, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855601, Free PMC Article
  5. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Wu S, et al. Nat Struct Mol Biol, 2007 Dec. PMID 18026119, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromatin remodeling factor, INO80, inhibits PMAIP1 in renal tubular cells via exchange of histone variant H2A.Z. for H2A.
    Title: Chromatin remodeling factor, INO80, inhibits PMAIP1 in renal tubular cells via exchange of histone variant H2A.Z. for H2A.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromatin-remodeling ATPase INO80
Names
DNA helicase INO80
INO80 complex homolog 1
INO80 complex subunit
INO80 homolog
putative DNA helicase INO80 complex homolog 1
NP_001248333.1
XP_038960477.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261404.2 → NP_001248333.1  chromatin-remodeling ATPase INO80

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ABX1, D4A6Q6
    Related
    ENSRNOP00000035575.7, ENSRNOT00000031672.8
    Conserved Domains (4) summary
    COG0553
    Location:350 → 868
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18793
    Location:1093 → 1228
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    cd18002
    Location:520 → 748
    DEXQc_INO80; DEAQ-box helicase domain of INO80
    pfam13892
    Location:275 → 404
    DBINO; DNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    126822280..126919532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104549.2 → XP_038960477.1  chromatin-remodeling ATPase INO80 isoform X1

    UniProtKB/TrEMBL
    A6HPF3
    Conserved Domains (2) summary
    COG0553
    Location:52 → 796
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18002
    Location:54 → 282
    DEXQc_INO80; DEAQ-box helicase domain of INO80
Nucleotide Protein Strain
Heading Accession and Version

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