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Pla2g4e phospholipase A2, group IVE [ Rattus norvegicus (Norway rat) ]

Gene ID: 296091, updated on 10-Oct-2024

Summary

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Official Symbol
Pla2g4eprovided by RGD
Official Full Name
phospholipase A2, group IVEprovided by RGD
Primary source
RGD:1310595
See related
EnsemblRapid:ENSRNOG00000024904 AllianceGenome:RGD:1310595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310595
Summary
Predicted to enable several functions, including calcium-dependent phospholipase A2 activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in N-acylphosphatidylethanolamine metabolic process; glycerophospholipid catabolic process; and positive regulation of endocytic recycling. Predicted to be located in early endosome membrane; lysosomal membrane; and plasma membrane. Predicted to be active in cytosol. Orthologous to human PLA2G4E (phospholipase A2 group IVE). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 24.9), Testes (RPKM 20.1) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pla2g4e in Genome Data Viewer
Location:
3q35
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127586318..127652369, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107132540..107198609, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111952396..112018470, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IVB Neighboring gene spectrin, beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4 Neighboring gene phospholipase A2 group IVD Neighboring gene phospholipase A2, group IVF

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytosolic phospholipase A₂ε drives recycling through the clathrin-independent endocytic route. Capestrano M, et al. J Cell Sci, 2014 Mar 1. PMID 24413173
  2. Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca(2+)-dependent N-acyltransferase. Hussain Z, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 May. PMID 29447909
  3. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. Ohto T, et al. J Biol Chem, 2005 Jul 1. PMID 15866882
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic phospholipase A2 epsilon
Names
phospholipase A2, group 4E
XP_017447688.1
XP_017447690.1
XP_017447691.1
XP_017447692.1
XP_017447693.1
XP_038962439.1
XP_038962441.1
XP_038962442.1
XP_038962444.1
XP_230487.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430038.1 → NP_001416967.1  cytosolic phospholipase A2 epsilon isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ANS2

  2. NM_001430039.1 → NP_001416968.1  cytosolic phospholipase A2 epsilon isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    127586318..127652369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_230487.10 → XP_230487.5  cytosolic phospholipase A2 epsilon isoform X2

    See identical proteins and their annotated locations for XP_230487.5

    UniProtKB/TrEMBL
    F1LPY6
    Related
    ENSRNOP00000031380.6, ENSRNOT00000030502.7
    Conserved Domains (3) summary
    cd04036
    Location:72 → 180
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:314 → 801
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit
    cl11396
    Location:318 → 860
    Patatin_and_cPLA2; Patatins and Phospholipases

  2. XM_017592204.3 → XP_017447693.1  cytosolic phospholipase A2 epsilon isoform X5

    Conserved Domains (3) summary
    pfam18695
    Location:133 → 240
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:239 → 781
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl14603
    Location:1 → 101
    C2; C2 domain

  3. XM_017592202.3 → XP_017447691.1  cytosolic phospholipase A2 epsilon isoform X4

  4. XM_039106511.2 → XP_038962439.1  cytosolic phospholipase A2 epsilon isoform X3

    UniProtKB/TrEMBL
    A0A8I6AKA4, F1LPY6
    Conserved Domains (3) summary
    cd04036
    Location:58 → 166
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:198 → 305
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:304 → 846
    Patatin_and_cPLA2; Patatins and Phospholipases

  5. XM_017592199.3 → XP_017447688.1  cytosolic phospholipase A2 epsilon isoform X1

    UniProtKB/TrEMBL
    F1LPY6
    Related
    ENSRNOP00000093379.2, ENSRNOT00000097961.2
    Conserved Domains (3) summary
    cd04036
    Location:107 → 215
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:247 → 354
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:353 → 895
    Patatin_and_cPLA2; Patatins and Phospholipases

  6. XM_017592201.3 → XP_017447690.1  cytosolic phospholipase A2 epsilon isoform X4

    UniProtKB/TrEMBL
    A0A8I6ANS2, F1LPY6

  7. XM_017592203.2 → XP_017447692.1  cytosolic phospholipase A2 epsilon isoform X4

    UniProtKB/TrEMBL
    A0A8I6ANS2, F1LPY6
    Related
    ENSRNOP00000095683.1, ENSRNOT00000109239.2

  8. XM_039106513.2 → XP_038962441.1  cytosolic phospholipase A2 epsilon isoform X6

    Conserved Domains (3) summary
    cd04036
    Location:107 → 215
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:247 → 354
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:353 → 712
    Patatin_and_cPLA2; Patatins and Phospholipases

  9. XM_039106514.2 → XP_038962442.1  cytosolic phospholipase A2 epsilon isoform X7

    Conserved Domains (3) summary
    cd04036
    Location:107 → 215
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:247 → 354
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:353 → 554
    Patatin_and_cPLA2; Patatins and Phospholipases

  10. XM_039106516.2 → XP_038962444.1  cytosolic phospholipase A2 epsilon isoform X8

    Conserved Domains (3) summary
    cd04036
    Location:107 → 215
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:247 → 354
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:353 → 448
    Patatin_and_cPLA2; Patatins and Phospholipases
Nucleotide Protein Strain
Heading Accession and Version

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