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Ptprm protein tyrosine phosphatase, receptor type, M [ Rattus norvegicus (Norway rat) ]

Gene ID: 29616, updated on 2-Nov-2024

Summary

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Official Symbol
Ptprmprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Mprovided by RGD
Primary source
RGD:620776
See related
EnsemblRapid:ENSRNOG00000011700 AllianceGenome:RGD:620776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cadherin binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; retina layer formation; and retinal ganglion cell axon guidance. Predicted to act upstream of or within vasodilation. Predicted to be located in several cellular components, including adherens junction; lamellipodium; and perinuclear region of cytoplasm. Predicted to be active in cell-cell junction. Orthologous to human PTPRM (protein tyrosine phosphatase receptor type M). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 344.0), Heart (RPKM 206.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptprm in Genome Data Viewer
Location:
9q37
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (114086380..114791000, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (106639573..107343698, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (114846095..115555261, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RAB12, member RAS oncogene family Neighboring gene thymocyte selection associated family member 3 Neighboring gene uncharacterized LOC120094812 Neighboring gene uncharacterized LOC108352014 Neighboring gene uncharacterized LOC120094813 Neighboring gene uncharacterized LOC120094856 Neighboring gene leucine rich repeat containing 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor-induced angiogenesis. Singleton PA, et al. Mol Cancer Ther, 2008 Jun. PMID 18566238
  2. E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. Oblander SA, et al. Mol Cell Neurosci, 2007 Mar. PMID 17276081, Free PMC Article
  3. PTPmu signaling via PKCdelta is instructive for retinal ganglion cell guidance. Ensslen SE, et al. Mol Cell Neurosci, 2004 Apr. PMID 15080886
  4. The receptor protein tyrosine phosphatase mu, PTPmu, regulates histogenesis of the chick retina. Ensslen SE, et al. Dev Biol, 2003 Dec 1. PMID 14623235
  5. Intramolecular interactions between the juxtamembrane domain and phosphatase domains of receptor protein-tyrosine phosphatase RPTPmu. Regulation of catalytic activity. Feiken E, et al. J Biol Chem, 2000 May 19. PMID 10809770

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retina layer formation ISO
Inferred from Sequence Orthology
more info
  
involved_in retina layer formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within vasodilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase mu
NP_001162103.1
XP_038939047.2
XP_038939053.2
XP_063122888.1
XP_063122890.1
XP_063122891.1
XP_063122892.1
XP_063122893.1
XP_063122894.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168632.2 → NP_001162103.1  receptor-type tyrosine-protein phosphatase mu isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K8V0, F1LPJ1
    Related
    ENSRNOP00000053204.3, ENSRNOT00000056366.6
    Conserved Domains (8) summary
    cd06263
    Location:27 → 182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:933 → 1187
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192 → 278
    IG_like; Immunoglobulin like
    cd00047
    Location:960 → 1187
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499 → 581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain

  2. NM_001431773.1 → NP_001418702.1  receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5ZPJ0

  3. NM_001431774.1 → NP_001418703.1  receptor-type tyrosine-protein phosphatase mu isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    114086380..114791000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266820.1 → XP_063122890.1  receptor-type tyrosine-protein phosphatase mu isoform X2

  2. XM_063266818.1 → XP_063122888.1  receptor-type tyrosine-protein phosphatase mu isoform X1

    Related
    ENSRNOP00000080359.1, ENSRNOT00000107262.2

  3. XM_039083125.2 → XP_038939053.2  receptor-type tyrosine-protein phosphatase mu isoform X4

  4. XM_039083119.2 → XP_038939047.2  receptor-type tyrosine-protein phosphatase mu isoform X3

  5. XM_063266821.1 → XP_063122891.1  receptor-type tyrosine-protein phosphatase mu isoform X5

  6. XM_063266822.1 → XP_063122892.1  receptor-type tyrosine-protein phosphatase mu isoform X6

  7. XM_063266823.1 → XP_063122893.1  receptor-type tyrosine-protein phosphatase mu isoform X7

  8. XM_063266824.1 → XP_063122894.1  receptor-type tyrosine-protein phosphatase mu isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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