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Pank2 pantothenate kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296167, updated on 10-Oct-2024

Summary

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Official Symbol
Pank2provided by RGD
Official Full Name
pantothenate kinase 2provided by RGD
Primary source
RGD:1305169
See related
EnsemblRapid:ENSRNOG00000025286 AllianceGenome:RGD:1305169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable pantothenate kinase activity. Predicted to be involved in angiogenesis; coenzyme A biosynthetic process; and regulation of lipid metabolic process. Predicted to act upstream of or within several processes, including mitochondrion morphogenesis; regulation of mitochondrial membrane potential; and spermatid development. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in pantothenate kinase-associated neurodegeneration. Orthologous to human PANK2 (pantothenate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 147.1), Lung (RPKM 132.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pank2 in Genome Data Viewer
Location:
3q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138936448..138974196)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118483382..118519551)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123807911..123841797)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene mitochondrial antiviral signaling protein Neighboring gene uncharacterized LOC134486155 Neighboring gene microRNA 103a-2 Neighboring gene ring finger protein 24 Neighboring gene uncharacterized LOC102550049 Neighboring gene family with sequence similarity 98, member B, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model. Brunetti D, et al. Hum Mol Genet, 2012 Dec 15. PMID 22983956, Free PMC Article
  2. Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Leoni V, et al. Mol Genet Metab, 2012 Mar. PMID 22221393, Free PMC Article
  3. Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Kuo YM, et al. Hum Mol Genet, 2005 Jan 1. PMID 15525657, Free PMC Article
  4. Localization and regulation of mouse pantothenate kinase 2. Leonardi R, et al. FEBS Lett, 2007 Oct 2. PMID 17825826, Free PMC Article
  5. Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism. Garcia M, et al. PLoS One, 2012. PMID 22815849, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aerobic respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
NOT located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pantothenate kinase 2, mitochondrial
Names
pantothenate kinase 2 (Hallervorden-Spatz syndrome)
NP_001099983.1
XP_017447073.1
XP_038960511.1
XP_038960512.1
XP_038960514.1
XP_038960515.1
XP_038960516.1
XP_063139403.1
XP_063139404.1
XP_063139405.1
XP_063139407.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106513.2 → NP_001099983.1  pantothenate kinase 2, mitochondrial

    See identical proteins and their annotated locations for NP_001099983.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HQD5, F1LT70
    Related
    ENSRNOP00000036035.6, ENSRNOT00000033554.7
    Conserved Domains (1) summary
    pfam03630
    Location:87 → 435
    Fumble

RNA

  1. NR_190881.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NR_190882.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NR_190883.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NR_190884.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138936448..138974196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104588.2 → XP_038960516.1  pantothenate kinase 2, mitochondrial isoform X9

    Conserved Domains (1) summary
    cl17037
    Location:117 → 236
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_039104586.2 → XP_038960514.1  pantothenate kinase 2, mitochondrial isoform X7

    Conserved Domains (1) summary
    cl17037
    Location:117 → 280
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_039104583.2 → XP_038960511.1  pantothenate kinase 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam03630
    Location:117 → 474
    Fumble

  4. XM_063283333.1 → XP_063139403.1  pantothenate kinase 2, mitochondrial isoform X1

  5. XM_017591584.3 → XP_017447073.1  pantothenate kinase 2, mitochondrial isoform X3

  6. XM_039104584.2 → XP_038960512.1  pantothenate kinase 2, mitochondrial isoform X5

    Conserved Domains (1) summary
    pfam03630
    Location:87 → 444
    Fumble

  7. XM_039104587.2 → XP_038960515.1  pantothenate kinase 2, mitochondrial isoform X8

    Conserved Domains (1) summary
    cl17037
    Location:87 → 250
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  8. XM_063283334.1 → XP_063139404.1  pantothenate kinase 2, mitochondrial isoform X4

  9. XM_063283337.1 → XP_063139407.1  pantothenate kinase 2, mitochondrial isoform X10

  10. XM_063283335.1 → XP_063139405.1  pantothenate kinase 2, mitochondrial isoform X6

RNA

  1. XR_010064584.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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