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Ndufaf5 NADH:ubiquinone oxidoreductase complex assembly factor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296190, updated on 2-Nov-2024

Summary

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Official Symbol
Ndufaf5provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase complex assembly factor 5provided by RGD
Primary source
RGD:1309829
See related
EnsemblRapid:ENSRNOG00000004784 AllianceGenome:RGD:1309829
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309829
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and oxidoreductase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine hydroxylation. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 16. Orthologous to human NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 166.4), Brain (RPKM 149.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ndufaf5 in Genome Data Viewer
Location:
3q41
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (147961612..147991128)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (127507931..127537477)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (133232412..133261932)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 87 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog Neighboring gene U6 spliceosomal RNA Neighboring gene SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase Neighboring gene mono-ADP ribosylhydrolase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease. Sugiana C, et al. Am J Hum Genet, 2008 Oct. PMID 18940309, Free PMC Article
  2. NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I. Rhein VF, et al. J Biol Chem, 2016 Jul 8. PMID 27226634, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-arginine hydroxylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-arginine hydroxylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in matrix side of mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
arginine-hydroxylase NDUFAF5, mitochondrial
Names
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5
probable methyltransferase C20orf7 homolog, mitochondrial
putative methyltransferase NDUFAF5
NP_001119843.1
XP_006235159.1
XP_038960521.1
XP_063139410.1
XP_063139411.1
XP_063139412.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126371.1 → NP_001119843.1  arginine-hydroxylase NDUFAF5, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001119843.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166551
    UniProtKB/Swiss-Prot
    B2GV71
    UniProtKB/TrEMBL
    A0A8I5ZTK1
    Related
    ENSRNOP00000006412.4, ENSRNOT00000006412.8
    Conserved Domains (2) summary
    TIGR02072
    Location:74 → 310
    BioC; malonyl-acyl carrier protein O-methyltransferase BioC
    pfam08241
    Location:94 → 185
    Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    147961612..147991128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235097.5 → XP_006235159.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam08241
    Location:94 → 185
    Methyltransf_11; Methyltransferase domain

  2. XM_063283341.1 → XP_063139411.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6HQM0

  3. XM_063283340.1 → XP_063139410.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6HQM0

  4. XM_039104593.2 → XP_038960521.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6HQM0

  5. XM_063283342.1 → XP_063139412.1  arginine-hydroxylase NDUFAF5, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6HQM0

RNA

  1. XR_005501826.2 RNA Sequence

  2. XR_005501827.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2GV71.1 GenPept UniProtKB/Swiss-Prot:B2GV71

Gene LinkOut

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