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Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29632, updated on 2-Nov-2024

Summary

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Symbol
Hsd3b2provided by RGD
Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2provided by RGD
Primary source
RGD:67377
See related
EnsemblRapid:ENSRNOG00000019441 AllianceGenome:RGD:67377
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hsd3b1; Hsd3b6; Hsd3b2l1
Summary
Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity and steroid delta-isomerase activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum; intercellular bridge; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hyperprolactinemia and hypertension. Human ortholog(s) of this gene implicated in hypospadias. Orthologous to human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 8657.9) See more
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Genomic context

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See Hsd3b2 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (188784614..188812535, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (186095897..186105354, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (200712895..200722429, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 Neighboring gene uncharacterized LOC134485937 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5, pseudogene 1 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin. Simard J, et al. J Biol Chem, 1993 Sep 15. PMID 7690038
  2. Opposite effects of prolactin and corticosterone on the expression and activity of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in rat skin. Couet J, et al. J Invest Dermatol, 1994 Jul. PMID 8027581
  3. Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary. Nampoothiri LP, et al. J Biochem Mol Toxicol, 2008 Sep-Oct. PMID 18972398
  4. Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells. Izumi S, et al. Acta Histochem, 2005. PMID 16139340
  5. Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Murrell JR, et al. Circulation, 2005 Aug 30. PMID 16116051

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lycopene protects against PCB-induced changes in Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD.
    Title: Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats.
  2. The expression of 3 beta-HSD, a converting enzyme of progesterone, is increased in dorsal root ganglion neurons following peripheral nerve injury.
    Title: Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury.
  3. The present studies showed differences in AR and 3beta-HSD distribution within various generations of corpora lutea (CL) and within particular regions of the same young CL.
    Title: Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109236

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables steroid delta-isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone dehydrogenase [NAD(P)+] activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in C21-steroid hormone biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in C21-steroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Leydig cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in androgen biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of iron ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to gonadotropin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
Names
3 beta-hydroxysteroid dehydrogenase 6
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV
3-beta-HSD IV
Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
hydroxysteroid dehydrogenase-6 delta<5>-3-beta
NP_058961.4
XP_063137742.1
XP_063137743.1
XP_063137744.1
XP_063137745.1
XP_063137746.1
XP_063137747.1
XP_063137748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017265.4 → NP_058961.4  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4

    See identical proteins and their annotated locations for NP_058961.4

    Status: PROVISIONAL

    Source sequence(s)
    BC089937
    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0, F1LNS3
    Related
    ENSRNOP00000026306.4, ENSRNOT00000026306.7
    Conserved Domains (2) summary
    pfam01073
    Location:7 → 287
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    cl21454
    Location:5 → 357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    188784614..188812535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281678.1 → XP_063137748.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0

  2. XM_063281676.1 → XP_063137746.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0

  3. XM_063281677.1 → XP_063137747.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0

  4. XM_063281674.1 → XP_063137744.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0

  5. XM_063281672.1 → XP_063137742.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0

  6. XM_063281673.1 → XP_063137743.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0

  7. XM_063281675.1 → XP_063137745.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVK0, Q62878
    UniProtKB/TrEMBL
    A6K3E0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62878.4 GenPept UniProtKB/Swiss-Prot:Q62878

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