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Kcng1 potassium voltage-gated channel modifier subfamily G member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296395, updated on 2-Nov-2024

Summary

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Official Symbol
Kcng1provided by RGD
Official Full Name
potassium voltage-gated channel modifier subfamily G member 1provided by RGD
Primary source
RGD:631416
See related
EnsemblRapid:ENSRNOG00000054314 AllianceGenome:RGD:631416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kh2; Kv6.1
Summary
Enables potassium channel regulator activity. Involved in potassium ion transport and regulation of potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. Orthologous to human KCNG1 (potassium voltage-gated channel modifier subfamily G member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 9.9), Uterus (RPKM 4.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcng1 in Genome Data Viewer
Location:
3q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (177379593..177412986, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (156960717..156992877, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (165020230..165040966, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene activity-dependent neuroprotector homeobox Neighboring gene dolichyl-phosphate mannosyltransferase subunit 1, catalytic Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene uncharacterized LOC134486480 Neighboring gene uncharacterized LOC120101792 Neighboring gene keratin-associated protein 4-3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Kramer JW, et al. Am J Physiol, 1998 Jun. PMID 9696692
  2. Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. Drewe JA, et al. J Neurosci, 1992 Feb. PMID 1740690, Free PMC Article
  3. Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. Post MA, et al. FEBS Lett, 1996 Dec 9. PMID 8980147
  4. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. Mederos Y Schnitzler M, et al. J Biol Chem, 2009 Feb 13. PMID 19074135
  5. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-gated potassium channel regulatory subunit KCNG1; potassium voltage-gated channel subfamily G member 1
Names
potassium channel, voltage-gated modifier subfamily G, member 1
potassium voltage-gated channel, subfamily G, member 1
voltage-gated potassium channel subunit Kv6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106545.2 → NP_001100015.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 1

    See identical proteins and their annotated locations for NP_001100015.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    D4AD53
    UniProtKB/TrEMBL
    A0A8I6ARM4
    Related
    ENSRNOP00000069311.1, ENSRNOT00000081648.3
    Conserved Domains (4) summary
    smart00225
    Location:65 → 169
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:256 → 471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65 → 164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383 → 465
    Ion_trans_2; Ion channel

  2. NM_001430296.1 → NP_001417225.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    D4AD53

  3. NM_001430297.1 → NP_001417226.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001430298.1 → NP_001417227.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001430299.1 → NP_001417228.1  voltage-gated potassium channel regulatory subunit KCNG1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    177379593..177412986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104646.2 → XP_038960574.1  potassium voltage-gated channel subfamily G member 1 isoform X3

    Conserved Domains (1) summary
    cd18421
    Location:60 → 173
    BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2

  2. XM_063283412.1 → XP_063139482.1  potassium voltage-gated channel subfamily G member 1 isoform X2

  3. XM_017591616.3 → XP_017447105.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    Conserved Domains (4) summary
    smart00225
    Location:65 → 169
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:256 → 471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65 → 164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383 → 465
    Ion_trans_2; Ion channel

  4. XM_039104645.2 → XP_038960573.1  potassium voltage-gated channel subfamily G member 1 isoform X2

    Conserved Domains (1) summary
    cd18421
    Location:60 → 173
    BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2

  5. XM_008762484.4 → XP_008760706.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    Conserved Domains (4) summary
    smart00225
    Location:65 → 169
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:256 → 471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65 → 164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383 → 465
    Ion_trans_2; Ion channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4AD53.1 GenPept UniProtKB/Swiss-Prot:D4AD53

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