Adam7 ADAM metallopeptidase domain 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam7provided by RGD
Official Full Name: ADAM metallopeptidase domain 7provided by RGD
Primary source: RGD:62032
See related: EnsemblRapid:ENSRNOG00000014054 AllianceGenome:RGD:62032
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EAP; ADAM; EAPI; EAP I; ADAM 7
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including epididymis development; positive regulation of flagellated sperm motility; and positive regulation of sperm capacitation. Located in apical part of cell. Orthologous to human ADAM7 (ADAM metallopeptidase domain 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 17.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (47009176..47057581, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (42833796..42882201, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (49418946..49467174, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM7, but not ADAM28, is transferred from the epididymis to the sperm surface and redistributed in the sperm head during acrosome reaction
Title: Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in epididymis development	IEA Inferred from Electronic Annotation more info
involved_in epididymis development	ISO Inferred from Sequence Orthology more info
involved_in epididymis development	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sperm capacitation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sperm capacitation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sperm capacitation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 7

Names: a disintegrin and metallopeptidase domain 7; a disintegrin and metalloprotease domain (ADAM) 7; a disintegrin and metalloprotease domain 7; epididymal apical protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020301.2 → NP_064697.2 disintegrin and metalloproteinase domain-containing protein 7 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q63180

UniProtKB/TrEMBL

A6K6R3, G3V7T7

Related

ENSRNOP00000019209.2, ENSRNOT00000019209.4

Conserved Domains (4) summary

smart00050
Location:410 → 482

DISIN; Homologues of snake disintegrins

smart00608
Location:486 → 623

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:199 → 393

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:28 → 156

Pep_M12B_propep; Reprolysin family propeptide