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Ppdpf pancreatic progenitor cell differentiation and proliferation factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 296470, updated on 2-Nov-2024

Summary

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Official Symbol
Ppdpfprovided by RGD
Official Full Name
pancreatic progenitor cell differentiation and proliferation factorprovided by RGD
Primary source
RGD:1310660
See related
EnsemblRapid:ENSRNOG00000012722 AllianceGenome:RGD:1310660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310660
Summary
Predicted to be involved in cell differentiation. Predicted to act upstream of or within TORC1 signaling and liver development. Predicted to be located in mitochondrion. Orthologous to human PPDPF (pancreatic progenitor cell differentiation and proliferation factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 171.9), Lung (RPKM 149.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppdpf in Genome Data Viewer
Location:
3q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188676821..188678599)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168299309..168301040)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176690507..176692272)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene uncharacterized LOC134486215 Neighboring gene protein tyrosine kinase 6 Neighboring gene uncharacterized LOC108350541 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108808

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within TOR signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
pancreatic progenitor cell differentiation and proliferation factor
Names
exocrine differentiation and proliferation factor
pancreatic progenitor cell differentiation and proliferation factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009316.2 → NP_001009316.1  pancreatic progenitor cell differentiation and proliferation factor

    See identical proteins and their annotated locations for NP_001009316.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5PR01
    UniProtKB/TrEMBL
    A6KM38
    Conserved Domains (1) summary
    pfam15060
    Location:1 → 111
    PPDFL; Differentiation and proliferation regulator

  2. NM_001431549.1 → NP_001418478.1  pancreatic progenitor cell differentiation and proliferation factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5PR01
    UniProtKB/TrEMBL
    A6KM38

  3. NM_001431550.1 → NP_001418479.1  pancreatic progenitor cell differentiation and proliferation factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5PR01
    UniProtKB/TrEMBL
    A6KM38

  4. NM_001431551.1 → NP_001418480.1  pancreatic progenitor cell differentiation and proliferation factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5PR01
    UniProtKB/TrEMBL
    A6KM38

  5. NM_001431552.1 → NP_001418481.1  pancreatic progenitor cell differentiation and proliferation factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5PR01
    UniProtKB/TrEMBL
    A6KM38

RNA

  1. NR_197231.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NR_197232.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NR_197233.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NR_197234.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188676821..188678599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235748.5 → XP_006235810.1  pancreatic progenitor cell differentiation and proliferation factor isoform X1

    Related
    ENSRNOP00000017319.3, ENSRNOT00000017319.7
    Conserved Domains (1) summary
    pfam15060
    Location:1 → 111
    PPDFL; Differentiation and proliferation regulator

  2. XM_006235746.5 → XP_006235808.1  pancreatic progenitor cell differentiation and proliferation factor isoform X1

    Conserved Domains (1) summary
    pfam15060
    Location:1 → 111
    PPDFL; Differentiation and proliferation regulator

  3. XM_039104694.2 → XP_038960622.1  pancreatic progenitor cell differentiation and proliferation factor isoform X1

    Conserved Domains (1) summary
    pfam15060
    Location:1 → 111
    PPDFL; Differentiation and proliferation regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PR01.1 GenPept UniProtKB/Swiss-Prot:Q5PR01

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