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Clic3 chloride intracellular channel 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296566, updated on 2-Nov-2024

Summary

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Official Symbol
Clic3provided by RGD
Official Full Name
chloride intracellular channel 3provided by RGD
Primary source
RGD:1307249
See related
EnsemblRapid:ENSRNOG00000015184 AllianceGenome:RGD:1307249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chloride channel activity and protein-disulfide reductase (glutathione) activity. Predicted to be involved in chloride transport and positive regulation of sprouting angiogenesis. Predicted to be located in extracellular matrix and nuclear body. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC3 (chloride intracellular channel 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 254.3), Kidney (RPKM 56.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Clic3 in Genome Data Viewer
Location:
3p13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28670176..28672166)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8271416..8274023)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2675732..2678248)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 7 Neighboring gene ATP binding cassette subfamily A member 2 Neighboring gene PAXX, non-homologous end joining factor Neighboring gene prostaglandin D2 synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. Qian Z, et al. J Biol Chem, 1999 Jan 15. PMID 9880541
  2. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109225

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-disulfide reductase (glutathione) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chloride intracellular channel protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013080.2 → NP_001013098.2  chloride intracellular channel protein 3

    See identical proteins and their annotated locations for NP_001013098.2

    Status: VALIDATED

    Source sequence(s)
    CF115110, CK841958
    UniProtKB/TrEMBL
    A0A8I5ZSV9, A6JT62, D3ZY91
    Related
    ENSRNOP00000081757.1, ENSRNOT00000095258.2
    Conserved Domains (1) summary
    TIGR00862
    Location:6 → 230
    O-ClC; intracellular chloride channel protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28670176..28672166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233590.5 → XP_006233652.1  chloride intracellular channel protein 3 isoform X1

    Conserved Domains (2) summary
    cd10299
    Location:69 → 201
    GST_C_CLIC3; C-terminal, alpha helical domain of Chloride Intracellular Channel 3
    cl00388
    Location:1 → 62
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version

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