U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GTF2H2 general transcription factor IIH subunit 2 [ Homo sapiens (human) ]

Gene ID: 2966, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
GTF2H2provided by HGNC
Official Full Name
general transcription factor IIH subunit 2provided by HGNC
Primary source
HGNC:HGNC:4656
See related
Ensembl:ENSG00000145736 MIM:601748; AllianceGenome:HGNC:4656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p44; BTF2; TFIIH; BTF2P44; BTF2 p44; T-BTF2P44
Summary
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 16.9), testis (RPKM 15.9) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GTF2H2 in Genome Data Viewer
Location:
5q13.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (71035347..71067676, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (71492061..71524378, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (70331174..70363503, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:70227603-70228594 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:70228664-70229392 Neighboring gene survival motor neuron- antisense 1 Neighboring gene survival of motor neuron 1, telomeric Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:70260097-70260788 Neighboring gene uncharacterized LOC112267942 Neighboring gene NLR family apoptosis inhibitory protein Neighboring gene NAIP promoter region Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:70362331-70362930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:70380837-70381338 Neighboring gene OCLN pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 13B-2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:70393075-70393946 Neighboring gene NAIP pseudogene 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The multiple roles of transcription/repair factor TFIIH. Svejstrup JQ, et al. Trends Biochem Sci, 1996 Sep. PMID 8870499
  2. A role of the C-terminal part of p44 in the promoter escape activity of transcription factor IIH. Tremeau-Bravard A, et al. J Biol Chem, 2001 Jul 20. PMID 11319235
  3. A multicopy transcription-repair gene, BTF2p44, maps to the SMA region and demonstrates SMA associated deletions. Carter TA, et al. Hum Mol Genet, 1997 Feb. PMID 9063743
  4. The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease. Bürglen L, et al. Am J Hum Genet, 1997 Jan. PMID 8981949, Free PMC Article
  5. Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis. Ren P, et al. Am J Respir Crit Care Med, 2007 Jun 1. PMID 17332483, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosome-derived GTF2H2 from Huh7 cells can inhibit endothelial cell viability, migration, tube formation, and permeability.
    Title: Exosome-derived GTF2H2 from Huh7 cells can inhibit endothelial cell viability, migration, tube formation, and permeability.
  2. The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair.
    Title: The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair.
  3. interface variants between the p34 and p44 subunits only mildly affected the association between the full length proteins and did not impinge on TFIIH activities due to the presence of an additional interface involving the C4 domain of p34.
    Title: The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.
  4. Advanced oxidation protein products down-regulate the expression of calcium transport channels through p44/42 MAPK signaling mechanisms in the small intestinal epithelium.
    Title: Advanced oxidation protein products decrease the expression of calcium transport channels in small intestinal epithelium via the p44/42 MAPK signaling pathway.
  5. Together, these results suggest that p44/WDR77 expression causes the non-sensitivity of proliferating cells to TGFbeta signaling, thereby contributing to cellular proliferation during lung tumorigenesis.
    Title: P44/WDR77 restricts the sensitivity of proliferating cells to TGFβ signaling.
  6. No correlation was found for p44 and occludin gene copy number and spinal muscular atrophy
    Title: Correlation of SMN2, NAIP, p44, H4F5 and Occludin genes copy number with spinal muscular atrophy phenotype in Tunisian patients.
  7. miR-27a was identified as a key regulator of p44 mRNA. Moreover, miR-27a was shown to destabilize the p44 subunit of the TFIIH complex during the G2-M phase, thereby modulating the transcriptional shutdown observed during this transition.
    Title: MicroRNA-27a regulates basal transcription by targeting the p44 subunit of general transcription factor IIH.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: A population-based study of genotypic and phenotypic variability in children with spinal muscular atrophy.
  9. p52 Mediates XPB function within the transcription/repair factor
    Title: p52 Mediates XPB function within the transcription/repair factor TFIIH.
  10. p44 of TFIIH has a role in binding to the nonstructural protein of Rift Valley fever virus to form nuclear filamentous structures
    Title: TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIH, polypeptide 2 (GTF2H2, 44kDa) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat TFIIH synergizes with HIV-1 Tat to induce transcription elongation from the HIV-1 LTR promoter PubMed
tat Interaction of HIV-1 Tat with TFIIH stimulates phosphorylation of Ser-5 of the RNA polymerase II C-terminal domain (CTD), which in turn also stimulates co-transcriptional capping of HIV-1 mRNA PubMed
tat TFIIH interacts with HIV-1 Tat as a component of the HIV-1 transcription preinitiation complex, but is released from the elongation complex which includes P-TEFb PubMed
tat CAK/TFIIH is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat Amino acids 1-48 of HIV-1 Tat, which includes the Tat activation domain, mediate the binding of Tat to CAK and the TFIIH complex through a direct interaction with CDK7 and possibly other TFIIH subunits, including p62 and ERCC3 PubMed
tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIH, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC102806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to UV TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of core TFIIH complex portion of holo TFIIH complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
general transcription factor IIH subunit 2
Names
TFIIH basal transcription factor complex p44 subunit
basic transcription factor 2 44 kDa subunit
general transcription factor IIH polypeptide 2
general transcription factor IIH, polypeptide 2, 44kD subunit
general transcription factor IIH, polypeptide 2, 44kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364567.2 → NP_001351496.1  general transcription factor IIH subunit 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Consensus CDS
    CCDS34183.1
    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (2) summary
    COG5151
    Location:11 → 385
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  2. NM_001364568.3 → NP_001351497.1  general transcription factor IIH subunit 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  3. NM_001364569.2 → NP_001351498.1  general transcription factor IIH subunit 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  4. NM_001364570.2 → NP_001351499.1  general transcription factor IIH subunit 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  5. NM_001364571.2 → NP_001351500.1  general transcription factor IIH subunit 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  6. NM_001364572.3 → NP_001351501.1  general transcription factor IIH subunit 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC044797
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (2) summary
    pfam04056
    Location:7 → 179
    Ssl1; Ssl1-like
    cl06838
    Location:231 → 289
    C1_4; TFIIH C1-like domain

  7. NM_001364573.3 → NP_001351502.1  general transcription factor IIH subunit 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC044797
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (2) summary
    cd01453
    Location:1 → 180
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:232 → 290
    C1_4; TFIIH C1-like domain

  8. NM_001395387.1 → NP_001382316.1  general transcription factor IIH subunit 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Consensus CDS
    CCDS34183.1
    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (2) summary
    COG5151
    Location:11 → 385
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  9. NM_001395388.1 → NP_001382317.1  general transcription factor IIH subunit 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Consensus CDS
    CCDS34183.1
    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41
    UniProtKB/TrEMBL
    B7ZW82
    Related
    ENSP00000328901.6, ENST00000330280.11
    Conserved Domains (2) summary
    COG5151
    Location:11 → 385
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  10. NM_001395389.1 → NP_001382318.1  general transcription factor IIH subunit 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC044797
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (1) summary
    COG5151
    Location:11 → 368
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]

  11. NM_001395390.1 → NP_001382319.1  general transcription factor IIH subunit 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 345
    C1_4; TFIIH C1-like domain

  12. NM_001395391.1 → NP_001382320.1  general transcription factor IIH subunit 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Consensus CDS
    CCDS34183.1
    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (2) summary
    COG5151
    Location:11 → 385
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  13. NM_001395392.1 → NP_001382321.1  general transcription factor IIH subunit 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Consensus CDS
    CCDS34183.1
    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (2) summary
    COG5151
    Location:11 → 385
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  14. NM_001395393.1 → NP_001382322.1  general transcription factor IIH subunit 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC044797
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (2) summary
    COG5151
    Location:11 → 384
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 235
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  15. NM_001395394.1 → NP_001382323.1  general transcription factor IIH subunit 2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  16. NM_001395395.1 → NP_001382324.1  general transcription factor IIH subunit 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC044797
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (1) summary
    COG5151
    Location:11 → 368
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]

  17. NM_001395396.1 → NP_001382325.1  general transcription factor IIH subunit 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC044797
    UniProtKB/TrEMBL
    B7ZW82
    Conserved Domains (1) summary
    COG5151
    Location:11 → 368
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]

  18. NM_001395397.1 → NP_001382326.1  general transcription factor IIH subunit 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  19. NM_001395398.1 → NP_001382327.1  general transcription factor IIH subunit 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  20. NM_001395399.1 → NP_001382328.1  general transcription factor IIH subunit 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Conserved Domains (2) summary
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...
    cl06838
    Location:288 → 346
    C1_4; TFIIH C1-like domain

  21. NM_001515.4 → NP_001506.1  general transcription factor IIH subunit 2 isoform a

    See identical proteins and their annotated locations for NP_001506.1

    Status: REVIEWED

    Source sequence(s)
    AC044797
    Consensus CDS
    CCDS34183.1
    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41
    UniProtKB/TrEMBL
    B7ZW82
    Related
    ENSP00000274400.5, ENST00000274400.10
    Conserved Domains (2) summary
    COG5151
    Location:11 → 385
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 236
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    71035347..71067676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417131.1 → XP_047273087.1  general transcription factor IIH subunit 2 isoform X2

  2. XM_047417130.1 → XP_047273086.1  general transcription factor IIH subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41

  3. XM_047417132.1 → XP_047273088.1  general transcription factor IIH subunit 2 isoform X3

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187651.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    583733..634364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329950.1 → XP_054185925.1  general transcription factor IIH subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41

  2. XM_054329949.1 → XP_054185924.1  general transcription factor IIH subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41

  3. XM_054329951.1 → XP_054185926.1  general transcription factor IIH subunit 2 isoform X2

  4. XM_054329948.1 → XP_054185923.1  general transcription factor IIH subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41

  5. XM_054329953.1 → XP_054185928.1  general transcription factor IIH subunit 2 isoform X3

  6. XM_054329952.1 → XP_054185927.1  general transcription factor IIH subunit 2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    71492061..71524378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352472.1 → XP_054208447.1  general transcription factor IIH subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q13888, Q15570, Q15571, Q9BS41

  2. XM_054352473.1 → XP_054208448.1  general transcription factor IIH subunit 2 isoform X2

  3. XM_054352474.1 → XP_054208449.1  general transcription factor IIH subunit 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13888.1 GenPept UniProtKB/Swiss-Prot:Q13888

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous