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Cercam cerebral endothelial cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 296616, updated on 2-Nov-2024

Summary

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Official Symbol
Cercamprovided by RGD
Official Full Name
cerebral endothelial cell adhesion moleculeprovided by RGD
Primary source
RGD:1304778
See related
EnsemblRapid:ENSRNOG00000026604 AllianceGenome:RGD:1304778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ceecam1
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human CERCAM (cerebral endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 21.7), Uterus (RPKM 20.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cercam in Genome Data Viewer
Location:
3p12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33515513..33553817)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13118150..13155960)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8421116..8444743)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 4 Neighboring gene ubiquitin related modifier 1 Neighboring gene uncharacterized LOC120101515 Neighboring gene microRNA 219-2 Neighboring gene microRNA 2964 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene GLE1 RNA export mediator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium. Starzyk RM, et al. J Infect Dis, 2000 Jan. PMID 10608765
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables procollagen galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable inactive glycosyltransferase 25 family member 3
Names
cerebral endothelial cell adhesion molecule 1
glycosyltransferase 25 family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415688.1 → NP_001402617.1  probable inactive glycosyltransferase 25 family member 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8L2RBI3, A6JTS9
    Related
    ENSRNOP00000075363.2, ENSRNOT00000090440.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33515513..33553817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283485.1 → XP_063139555.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5U309

  2. XM_063283487.1 → XP_063139557.1  probable inactive glycosyltransferase 25 family member 3 isoform X3

  3. XM_063283488.1 → XP_063139558.1  probable inactive glycosyltransferase 25 family member 3 isoform X3

    Related
    ENSRNOP00000109487.1, ENSRNOT00000158082.1

  4. XM_017591646.3 → XP_017447135.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5U309
    UniProtKB/TrEMBL
    A0A0H2UI04
    Conserved Domains (1) summary
    cd06532
    Location:298 → 480
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

  5. XM_063283486.1 → XP_063139556.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5U309
    Related
    ENSRNOP00000112333.1, ENSRNOT00000131573.1

  6. XM_006233769.5 → XP_006233831.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

    See identical proteins and their annotated locations for XP_006233831.1

    UniProtKB/Swiss-Prot
    Q5U309
    UniProtKB/TrEMBL
    A0A0H2UI04
    Related
    ENSRNOP00000057689.4, ENSRNOT00000060969.5
    Conserved Domains (1) summary
    cd06532
    Location:298 → 480
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

  7. XM_006233771.5 → XP_006233833.1  probable inactive glycosyltransferase 25 family member 3 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UI04
    Conserved Domains (2) summary
    cd06532
    Location:277 → 459
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
    cl11394
    Location:38 → 82
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  8. XM_039104737.2 → XP_038960665.1  probable inactive glycosyltransferase 25 family member 3 isoform X4

    UniProtKB/TrEMBL
    A0A0H2UI04
    Conserved Domains (1) summary
    cd06532
    Location:243 → 425
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

  9. XM_063283489.1 → XP_063139559.1  probable inactive glycosyltransferase 25 family member 3 isoform X4

RNA

  1. XR_010064603.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001011962.1: Suppressed sequence

    Description
    NM_001011962.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U309.2 GenPept UniProtKB/Swiss-Prot:Q5U309

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